The Polo-Like Kinase 1 (PLK1) Inhibitor NMS-P937 Is Effective in a New Model of Disseminated Primary CD56+ Acute Monoblastic Leukaemia

Alessia Casolaro; Josee Golay; Clara Albanese; Roberta Ceruti; Veronica Patton; Sabrina Cribioli; Alice Pezzoni; Marco Losa; Gemma Texido; Ursula Giussani; Francesco Marchesi; Nadia Amboldi; Barbara Valsasina; Silvia Bungaro; Gianni Cazzaniga; Alessandro Rambaldi; Martino Introna; Enrico Pesenti; Rachele Alzani

doi:10.1371/journal.pone.0058424

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Peer-reviewed

Research Article

The Polo-Like Kinase 1 (PLK1) Inhibitor NMS-P937 Is Effective in a New Model of Disseminated Primary CD56⁺ Acute Monoblastic Leukaemia

Alessia Casolaro ,

Contributed equally to this work with: Alessia Casolaro, Josee Golay

Affiliation Oncology, Nerviano Medical Sciences, Nerviano, Milano, Italy
⨯
Josee Golay ,

Contributed equally to this work with: Alessia Casolaro, Josee Golay

Affiliation Laboratory of Cellular Therapy “G. Lanzani”, USC Haematology, Ospedali Riuniti, Bergamo, Italy
⨯
Clara Albanese,

Affiliation Oncology, Nerviano Medical Sciences, Nerviano, Milano, Italy
⨯
Roberta Ceruti,

Affiliation Oncology, Nerviano Medical Sciences, Nerviano, Milano, Italy
⨯
Veronica Patton,

Affiliation Oncology, Nerviano Medical Sciences, Nerviano, Milano, Italy
⨯
Sabrina Cribioli,

Affiliation Oncology, Nerviano Medical Sciences, Nerviano, Milano, Italy
⨯
Alice Pezzoni,

Affiliation Department of Oncology and Haematology, Istituto Clinico Humanitas, Rozzano, Milano, Italy
⨯
Marco Losa,

Affiliation Pathology, Fondazione Filarete, Milano, Italy
⨯
Gemma Texido,

Affiliation Oncology, Nerviano Medical Sciences, Nerviano, Milano, Italy
⨯
Ursula Giussani,

Affiliation Department of Medical Genetics, Ospedali Riuniti, Bergamo, Italy
⨯
Francesco Marchesi,

Affiliation Pathology, Accelera S.r.l., Nerviano, Milano, Italy
⨯
Nadia Amboldi,

Affiliation Oncology, Nerviano Medical Sciences, Nerviano, Milano, Italy
⨯
Barbara Valsasina,

Affiliation Oncology, Nerviano Medical Sciences, Nerviano, Milano, Italy
⨯
Silvia Bungaro,

Affiliation Tettamanti Research Center, Pediatric Clinic, University of Milano–Bicocca, Monza, Italy
⨯
Gianni Cazzaniga,

Affiliation Tettamanti Research Center, Pediatric Clinic, University of Milano–Bicocca, Monza, Italy
⨯
Alessandro Rambaldi,

Affiliation Laboratory of Cellular Therapy “G. Lanzani”, USC Haematology, Ospedali Riuniti, Bergamo, Italy
⨯
Martino Introna,

Affiliation Laboratory of Cellular Therapy “G. Lanzani”, USC Haematology, Ospedali Riuniti, Bergamo, Italy
⨯
Enrico Pesenti,

Affiliation Oncology, Nerviano Medical Sciences, Nerviano, Milano, Italy
⨯
[ ... ],
Rachele Alzani

* E-mail: rachele.alzani@nervianoms.com

Affiliation Oncology, Nerviano Medical Sciences, Nerviano, Milano, Italy
⨯
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The Polo-Like Kinase 1 (PLK1) Inhibitor NMS-P937 Is Effective in a New Model of Disseminated Primary CD56⁺ Acute Monoblastic Leukaemia

Alessia Casolaro,
Josee Golay,
Clara Albanese,
Roberta Ceruti,
Veronica Patton,
Sabrina Cribioli,
Alice Pezzoni,
Marco Losa,
Gemma Texido,
Ursula Giussani

Published: March 8, 2013
https://doi.org/10.1371/journal.pone.0058424

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