Klotho Endows Hepatoma Cells with Resistance to Anoikis via VEGFR2/PAK1 Activation in Hepatocellular Carcinoma

Lin Chen; Haiou Liu; Jing Liu; Yu Zhu; Le Xu; Hongyong He; Heng Zhang; Shanshan Wang; Qian Wu; Weisi Liu; Yidong Liu; Deng Pan; Shifang Ren; Jiejie Xu; Jianxin Gu

doi:10.1371/journal.pone.0058413

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Open Access

Peer-reviewed

Research Article

Klotho Endows Hepatoma Cells with Resistance to Anoikis via VEGFR2/PAK1 Activation in Hepatocellular Carcinoma

Lin Chen ,

Contributed equally to this work with: Lin Chen, Haiou Liu

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China
⨯
Haiou Liu ,

Contributed equally to this work with: Lin Chen, Haiou Liu

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China
⨯
Jing Liu,

Affiliation School of Medicine, Nantong University, Nantong, China
⨯
Yu Zhu,

Affiliation Department of Urology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
⨯
Le Xu,

Affiliation Department of Urology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
⨯
Hongyong He,

Affiliation Department of General Surgery, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
⨯
Heng Zhang,

Affiliation Department of General Surgery, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
⨯
Shanshan Wang,

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China
⨯
Qian Wu,

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China
⨯
Weisi Liu,

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China
⨯
Yidong Liu,

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China
⨯
Deng Pan,

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China
⨯
Shifang Ren,

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China
⨯
Jiejie Xu ,

* E-mail: jjxufdu@fudan.edu.cn

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China
⨯
Jianxin Gu

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China
⨯

Klotho Endows Hepatoma Cells with Resistance to Anoikis via VEGFR2/PAK1 Activation in Hepatocellular Carcinoma

Lin Chen,
Haiou Liu,
Jing Liu,
Yu Zhu,
Le Xu,
Hongyong He,
Heng Zhang,
Shanshan Wang,
Qian Wu,
Weisi Liu

Published: March 13, 2013
https://doi.org/10.1371/journal.pone.0058413

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Transfection
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