Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer

Longjiang Shao; Zhansong Zhou; Yi Cai; Patricia Castro; Olga Dakhov; Ping Shi; Yaoxia Bai; Huixiang Ji; Wenhao Shen; Jianghua Wang

doi:10.1371/journal.pone.0058391

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Open Access

Peer-reviewed

Research Article

Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer

Longjiang Shao ,

Contributed equally to this work with: Longjiang Shao, Zhansong Zhou

Affiliation Department of Pathology and Immunology, Baylor College of Medicine and Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, Texas, United States of America
⨯
Zhansong Zhou ,

Contributed equally to this work with: Longjiang Shao, Zhansong Zhou

Affiliation Department of Urology, South West Hospital, Chongqing, People's Republic of China
⨯
Yi Cai,

Affiliation Department of Pathology and Immunology, Baylor College of Medicine and Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, Texas, United States of America
⨯
Patricia Castro,

Affiliation Department of Pathology and Immunology, Baylor College of Medicine and Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, Texas, United States of America
⨯
Olga Dakhov,

Affiliation Department of Pathology and Immunology, Baylor College of Medicine and Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, Texas, United States of America
⨯
Ping Shi,

Affiliation Department of Urology, South West Hospital, Chongqing, People's Republic of China
⨯
Yaoxia Bai,

Affiliation Department of Urology, South West Hospital, Chongqing, People's Republic of China
⨯
Huixiang Ji,

Affiliation Department of Urology, South West Hospital, Chongqing, People's Republic of China
⨯
Wenhao Shen,

Affiliation Department of Urology, South West Hospital, Chongqing, People's Republic of China
⨯
Jianghua Wang

* E-mail: jwang1@bcm.edu

Affiliation Department of Pathology and Immunology, Baylor College of Medicine and Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, Texas, United States of America
⨯

Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer

Longjiang Shao,
Zhansong Zhou,
Yi Cai,
Patricia Castro,
Olga Dakhov,
Ping Shi,
Yaoxia Bai,
Huixiang Ji,
Wenhao Shen,
Jianghua Wang

Published: March 6, 2013
https://doi.org/10.1371/journal.pone.0058391

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Cancers and neoplasms
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Cell fusion
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Cell growth
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