Does DNA Methylation of PPARGC1A Influence Insulin Action in First Degree Relatives of Patients with Type 2 Diabetes?

Linn Gillberg; Stine Jacobsen; Rasmus Ribel-Madsen; Anette Prior Gjesing; Trine W. Boesgaard; Charlotte Ling; Oluf Pedersen; Torben Hansen; Allan Vaag

doi:10.1371/journal.pone.0058384

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Peer-reviewed

Research Article

Does DNA Methylation of PPARGC1A Influence Insulin Action in First Degree Relatives of Patients with Type 2 Diabetes?

Linn Gillberg ,

* E-mail: linn.gillberg@rh.regionh.dk

Affiliations Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark, Steno Diabetes Center, Gentofte, Denmark
⨯
Stine Jacobsen,

Affiliations Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark, Steno Diabetes Center, Gentofte, Denmark
⨯
Rasmus Ribel-Madsen,

Affiliation Section of Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Anette Prior Gjesing,

Affiliation Section of Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Trine W. Boesgaard,

Affiliations Steno Diabetes Center, Gentofte, Denmark, Hagedorn Research Institute, Gentofte, Denmark
⨯
Charlotte Ling,

Affiliation Department of Clinical Sciences, Lund University, Malmoe, Sweden
⨯
Oluf Pedersen,

Affiliations Section of Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Hagedorn Research Institute, Gentofte, Denmark, Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark
⨯
Torben Hansen,

Affiliations Section of Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
⨯
Allan Vaag

Affiliations Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark, Steno Diabetes Center, Gentofte, Denmark, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
⨯

Does DNA Methylation of PPARGC1A Influence Insulin Action in First Degree Relatives of Patients with Type 2 Diabetes?

Linn Gillberg,
Stine Jacobsen,
Rasmus Ribel-Madsen,
Anette Prior Gjesing,
Trine W. Boesgaard,
Charlotte Ling,
Oluf Pedersen,
Torben Hansen,
Allan Vaag

Published: March 7, 2013
https://doi.org/10.1371/journal.pone.0058384

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DNA methylation
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Insulin
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Gene expression
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Skeletal muscles
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Type 2 diabetes
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Insulin resistance
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Glucose tolerance
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DNA transcription
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