Orientations and Proximities of the Extracellular Ends of Transmembrane Helices S0 and S4 in Open and Closed BK Potassium Channels

• Xiaowei Niu ,

  Contributed equally to this work with: Xiaowei Niu, Guoxia Liu

  Affiliation From the Center for Molecular Recognition, Departments of Biochemistry, Physiology, and Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

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• Guoxia Liu ,

  Contributed equally to this work with: Xiaowei Niu, Guoxia Liu

  Affiliation Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

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• Roland S. Wu,

  Affiliation Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

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• Neelesh Chudasama,

  Affiliation Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

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• Sergey I. Zakharov,

  Affiliation Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

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• Arthur Karlin ,

  * E-mail: ak12@columbia.edu (AK); sm460@columbia.edu (SOM)

  Affiliation From the Center for Molecular Recognition, Departments of Biochemistry, Physiology, and Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

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• Steven O. Marx

  * E-mail: ak12@columbia.edu (AK); sm460@columbia.edu (SOM)

  Affiliations Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America, Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

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