Whole-Genome Thermodynamic Analysis Reduces siRNA Off-Target Effects

Open Access

Peer-reviewed

Research Article

Xi Chen,

Affiliation Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa, United States of America
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Peng Liu,

Affiliation Department of Statistics, Iowa State University, Ames, Iowa, United States of America
⨯
Hui-Hsien Chou

* E-mail: hhchou@iastate.edu

Affiliations Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa, United States of America, Department of Computer Science, Iowa State University, Ames, Iowa, United States of America
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Small interfering RNA
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Thermodynamics
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Gene prediction
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Melting
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Gene expression
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BLAST algorithm
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Transfection
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Computer software
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