Inactivation of DNA–Dependent Protein Kinase Promotes Heat–Induced Apoptosis Independently of Heat–Shock Protein Induction in Human Cancer Cell Lines

Seisuke Okazawa; Yukihiro Furusawa; Ayako Kariya; Mariame Ali Hassan; Mie Arai; Ryuji Hayashi; Yoshiaki Tabuchi; Takashi Kondo; Kazuyuki Tobe

doi:10.1371/journal.pone.0058325

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Peer-reviewed

Research Article

Inactivation of DNA–Dependent Protein Kinase Promotes Heat–Induced Apoptosis Independently of Heat–Shock Protein Induction in Human Cancer Cell Lines

Seisuke Okazawa,

Affiliations First Department of Internal Medicine, Graduate School of Medicine Pharmaceutical Sciences, University of Toyama, Toyama, Japan, Department of Radiological Sciences, Graduate School of Medicine Pharmaceutical Sciences, University of Toyama, Toyama, Japan
⨯
Yukihiro Furusawa,

Affiliation Department of Radiological Sciences, Graduate School of Medicine Pharmaceutical Sciences, University of Toyama, Toyama, Japan
⨯
Ayako Kariya,

Affiliation Department of Radiological Sciences, Graduate School of Medicine Pharmaceutical Sciences, University of Toyama, Toyama, Japan
⨯
Mariame Ali Hassan,

Affiliations Department of Radiological Sciences, Graduate School of Medicine Pharmaceutical Sciences, University of Toyama, Toyama, Japan, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
⨯
Mie Arai,

Affiliation Department of Radiological Sciences, Graduate School of Medicine Pharmaceutical Sciences, University of Toyama, Toyama, Japan
⨯
Ryuji Hayashi,

Affiliation First Department of Internal Medicine, Graduate School of Medicine Pharmaceutical Sciences, University of Toyama, Toyama, Japan
⨯
Yoshiaki Tabuchi,

Affiliation Division of Molecular Genetics Research, Life Science Research Center, Graduate School of Medicine Pharmaceutical Sciences, University of Toyama, Toyama, Japan
⨯
Takashi Kondo,

Affiliation Department of Radiological Sciences, Graduate School of Medicine Pharmaceutical Sciences, University of Toyama, Toyama, Japan
⨯
Kazuyuki Tobe

* E-mail: tobe@med.u-toyama.ac.jp

Affiliation First Department of Internal Medicine, Graduate School of Medicine Pharmaceutical Sciences, University of Toyama, Toyama, Japan
⨯

Inactivation of DNA–Dependent Protein Kinase Promotes Heat–Induced Apoptosis Independently of Heat–Shock Protein Induction in Human Cancer Cell Lines

Seisuke Okazawa,
Yukihiro Furusawa,
Ayako Kariya,
Mariame Ali Hassan,
Mie Arai,
Ryuji Hayashi,
Yoshiaki Tabuchi,
Takashi Kondo,
Kazuyuki Tobe

Published: March 11, 2013
https://doi.org/10.1371/journal.pone.0058325

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Thermal stresses
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Transfection
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Small interfering RNA
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HeLa cells
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