Altered Expression of MGMT in High-Grade Gliomas Results from the Combined Effect of Epigenetic and Genetic Aberrations

• João Ramalho-Carvalho,

  Affiliations Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal, Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal

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• Malini Pires,

  Affiliations Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal, Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal

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• Susana Lisboa,

  Affiliation Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal

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• Inês Graça,

  Affiliations Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal, Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal

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• Patrícia Rocha,

  Affiliation Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal

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• João Diogo Barros-Silva,

  Affiliations Cancer Genetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal, Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal

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• Joana Savva-Bordalo,

  Affiliations Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal, Department of Medical Oncology, Portuguese Oncology Institute-Porto, Porto, Portugal

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• Joaquina Maurício,

  Affiliation Department of Medical Oncology, Portuguese Oncology Institute-Porto, Porto, Portugal

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• Mário Resende,

  Affiliation Department of Neurosurgery, Local Health Unit of Matosinhos - Hospital Pedro Hispano, Matosinhos, Portugal

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• Manuel R. Teixeira,

  Affiliations Cancer Genetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal, Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal, Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal

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• Mrinalini Honavar,

  Affiliation Department of Pathology, Local Health Unit of Matosinhos - Hospital Pedro Hispano, Matosinhos, Portugal

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• Rui Henrique,

  Affiliations Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal, Department of Pathology, Portuguese Oncology Institute-Porto, Porto, Portugal, Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal

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• Carmen Jerónimo

  * E-mail: carmenjeronimo@ipoporto.min-saude.pt

  Affiliations Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal, Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal, Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal

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