Rare Genomic Structural Variants in Complex Disease: Lessons from the Replication of Associations with Obesity

• Robin G. Walters,

  Affiliations Department of Genomics of Common Disease, Imperial College London, London, United Kingdom, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom

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• Lachlan J. M. Coin,

  Affiliations Department of Genomics of Common Disease, Imperial College London, London, United Kingdom, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

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• Aimo Ruokonen,

  Affiliations Institute of Diagnostics, Clinical Chemistry, University of Oulu, Oulu, Finland, Oulu University Hospital, Oulu, Finland

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• Adam J. de Smith,

  Affiliations Department of Genomics of Common Disease, Imperial College London, London, United Kingdom, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America

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• Julia S. El-Sayed Moustafa,

  Affiliation Department of Genomics of Common Disease, Imperial College London, London, United Kingdom

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• Sebastien Jacquemont,

  Affiliation Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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• Paul Elliott,

  Affiliations Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, United Kingdom

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• Tõnu Esko,

  Affiliations Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia, Estonian Genome Center, University of Tartu, Tartu, Estonia

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• Anna-Liisa Hartikainen,

  Affiliation Institute of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland

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• Jaana Laitinen,

  Affiliation Finnish Institute of Occupational Health, Oulu, Finland

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• Katrin Männik,

  Affiliations Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia, The Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

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• Danielle Martinet,

  Affiliation Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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• David Meyre,

  Affiliations CNRS 8199-Institute of Biology, Pasteur Institute, Lille, France, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

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• Matthias Nauck,

  Affiliation Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany

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• Claudia Schurmann,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University, Greifswald, Germany

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• Rob Sladek,

  Affiliations McGill University and Genome Quebec Innovation Centre, Montreal, Canada, Department of Medicine and Human Genetics, McGill University, Montreal, Canada

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• Gudmar Thorleifsson,

  Affiliation deCODE Genetics, Reykjavík, Iceland

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• Unnur Thorsteinsdóttir,

  Affiliations deCODE Genetics, Reykjavík, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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• Armand Valsesia,

  Affiliations Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland

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• Gerard Waeber,

  Affiliation Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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• Flore Zufferey,

  Affiliation Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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• Beverley Balkau,

  Affiliations INSERM, CESP Centre for Research in Epidemiology and Population Health, U1018, Villejuif, France, University Paris Sud 11, UMRS 1018, Villejuif, France

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• François Pattou,

  Affiliations INSERM U859, Lille, France, Université Lille Nord de France, Centre Hospitalier Universitaire Lille, Lille, France

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• Andres Metspalu,

  Affiliations Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia, Estonian Genome Center, University of Tartu, Tartu, Estonia

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• Henry Völzke,

  Affiliation Institute for Community Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany

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• Peter Vollenweider,

  Affiliation Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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• Kári Stefansson,

  Affiliations deCODE Genetics, Reykjavík, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

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• Marjo-Riitta Järvelin,

  Affiliations Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, United Kingdom, Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland

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• Jacques S. Beckmann,

  Affiliations Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland

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• Philippe Froguel ,

  * E-mail: a.blakemore@imperial.ac.uk (AIFB); p.froguel@imperial.ac.uk (PF)

  Affiliations Department of Genomics of Common Disease, Imperial College London, London, United Kingdom, CNRS 8199-Institute of Biology, Pasteur Institute, Lille, France

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•  [ ... ],
• Alexandra I. F. Blakemore

  * E-mail: a.blakemore@imperial.ac.uk (AIFB); p.froguel@imperial.ac.uk (PF)

  Affiliations Department of Genomics of Common Disease, Imperial College London, London, United Kingdom, Section of Investigative Medicine, Imperial College London, London, United Kingdom

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