Development of Allogeneic NK Cell Adoptive Transfer Therapy in Metastatic Melanoma Patients: In Vitro Preclinical Optimization Studies

Michal J. Besser; Tsipi Shoham; Orit Harari-Steinberg; Naama Zabari; Rona Ortenberg; Arkadi Yakirevitch; Arnon Nagler; Ron Loewenthal; Jacob Schachter; Gal Markel

doi:10.1371/journal.pone.0057922

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Open Access

Peer-reviewed

Research Article

Development of Allogeneic NK Cell Adoptive Transfer Therapy in Metastatic Melanoma Patients: In Vitro Preclinical Optimization Studies

Michal J. Besser,

Affiliations Ella Institute of Melanoma, Sheba Medical Center, Tel Hashomer, Israel, Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, GreenOnyx, Israel
⨯
Tsipi Shoham,

Affiliation GreenOnyx, Tel Aviv, Israel
⨯
Orit Harari-Steinberg,

Affiliations Ella Institute of Melanoma, Sheba Medical Center, Tel Hashomer, Israel, Pediatric Stem Cell Research Institute, Sheba Medical Center, Tel Hashomer, Israel
⨯
Naama Zabari,

Affiliations Ella Institute of Melanoma, Sheba Medical Center, Tel Hashomer, Israel, Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, GreenOnyx, Israel
⨯
Rona Ortenberg,

Affiliations Ella Institute of Melanoma, Sheba Medical Center, Tel Hashomer, Israel, Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, GreenOnyx, Israel
⨯
Arkadi Yakirevitch,

Affiliation Department of Otolaryngology and Head and Neck Surgery, Sheba Medical Center, Tel Hashomer, Israel
⨯
Arnon Nagler,

Affiliation Division of Hematology, Sheba Medical Center, Tel Hashomer, Israel
⨯
Ron Loewenthal,

Affiliation Tissue Typing Laboratory, Sheba Medical Center, Tel Hashomer, Israel
⨯
Jacob Schachter,

Affiliation Ella Institute of Melanoma, Sheba Medical Center, Tel Hashomer, Israel
⨯
Gal Markel

* E-mail: markel@post.tau.ac.il

Affiliations Ella Institute of Melanoma, Sheba Medical Center, Tel Hashomer, Israel, Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, GreenOnyx, Israel, Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Israel
⨯

Development of Allogeneic NK Cell Adoptive Transfer Therapy in Metastatic Melanoma Patients: In Vitro Preclinical Optimization Studies

Michal J. Besser,
Tsipi Shoham,
Orit Harari-Steinberg,
Naama Zabari,
Rona Ortenberg,
Arkadi Yakirevitch,
Arnon Nagler,
Ron Loewenthal,
Jacob Schachter,
Gal Markel

Published: March 4, 2013
https://doi.org/10.1371/journal.pone.0057922

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NK cells
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Melanoma
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Melanoma cells
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T cells
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Flow cytometry
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Cytotoxicity
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Cloning
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Homozygosity
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