Native Tertiary Structure and Nucleoside Modifications Suppress tRNA’s Intrinsic Ability to Activate the Innate Immune Sensor PKR

• Subba Rao Nallagatla,

  Current address: AuraSense Therapeutics, Skokie, Illinois, United States of America

  Affiliation Department of Chemistry and Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Christie N. Jones,

  Current address: Department of Chemistry, Trinity University, San Antonio, Texas, United States of America

  Affiliation Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina, United States of America

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• Saikat Kumar B. Ghosh,

  Affiliation Department of Chemistry and Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Suresh D. Sharma,

  Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Craig E. Cameron,

  Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Linda L. Spremulli,

  Affiliation Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina, United States of America

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• Philip C. Bevilacqua

  * E-mail: pcb5@psu.edu

  Affiliation Department of Chemistry and Center for RNA Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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