Transcriptome Analysis of Proximal Tubular Cells (HK-2) Exposed to Urines of Type 1 Diabetes Patients at Risk of Early Progressive Renal Function Decline

Krzysztof Wanic; Bozena Krolewski; Wenjun Ju; Grzegorz Placha; Monika A. Niewczas; William Walker; James H. Warram; Matthias Kretzler; Andrzej S. Krolewski

doi:10.1371/journal.pone.0057751

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Peer-reviewed

Research Article

Transcriptome Analysis of Proximal Tubular Cells (HK-2) Exposed to Urines of Type 1 Diabetes Patients at Risk of Early Progressive Renal Function Decline

Krzysztof Wanic,

Affiliations Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Metabolic Diseases, Jagiellonian University, Krakow, Poland
⨯
Bozena Krolewski,

Affiliations Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Wenjun Ju,

Affiliation Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Grzegorz Placha,

Affiliations Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Hypertension, Warsaw Medical University, Warsaw, Poland
⨯
Monika A. Niewczas,

Affiliations Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
William Walker,

Affiliation Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
James H. Warram,

Affiliation Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Matthias Kretzler,

Affiliation Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Andrzej S. Krolewski

* E-mail: Andrzej.Krolewski@joslin.harvard.edu

Affiliations Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Transcriptome Analysis of Proximal Tubular Cells (HK-2) Exposed to Urines of Type 1 Diabetes Patients at Risk of Early Progressive Renal Function Decline

Krzysztof Wanic,
Bozena Krolewski,
Wenjun Ju,
Grzegorz Placha,
Monika A. Niewczas,
William Walker,
James H. Warram,
Matthias Kretzler,
Andrzej S. Krolewski

Published: March 7, 2013
https://doi.org/10.1371/journal.pone.0057751

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Urine
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Gene expression
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Cellular stress responses
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Glomerular filtration rate
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Renal system
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Biopsy
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Kidneys
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Diabetes mellitus
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