Feedback Regulations of miR-21 and MAPKs via Pdcd4 and Spry1 Are Involved in Arsenite-Induced Cell Malignant Transformation

Lu Shen; Min Ling; Yuan Li; Yuan Xu; Yun Zhou; Jing Ye; Ying Pang; Yue Zhao; Rongrong Jiang; Jianping Zhang; Qizhan Liu

doi:10.1371/journal.pone.0057652

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Open Access

Peer-reviewed

Research Article

Feedback Regulations of miR-21 and MAPKs via Pdcd4 and Spry1 Are Involved in Arsenite-Induced Cell Malignant Transformation

Lu Shen ,

Contributed equally to this work with: Lu Shen, Min Ling

Affiliations Institute of Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China
⨯
Min Ling ,

Contributed equally to this work with: Lu Shen, Min Ling

Affiliations Institute of Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China, Jiangsu Center for Disease Control and Prevention, Nanjing, Jiangsu, People’s Republic of China
⨯
Yuan Li,

Affiliations Institute of Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China
⨯
Yuan Xu,

Affiliations Institute of Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China
⨯
Yun Zhou,

Affiliation Department of General Surgery, the Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯
Jing Ye,

Affiliation Department of General Surgery, the Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯
Ying Pang,

Affiliations Institute of Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China
⨯
Yue Zhao,

Affiliations Institute of Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China
⨯
Rongrong Jiang,

Affiliations Institute of Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China
⨯
Jianping Zhang ,

* E-mail: zhang_jp64@yahoo.com.cn (JZ); drqzliu@hotmail.com (QL)

Affiliation Department of General Surgery, the Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯
Qizhan Liu

* E-mail: zhang_jp64@yahoo.com.cn (JZ); drqzliu@hotmail.com (QL)

Affiliations Institute of Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China, The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing, Jiangsu, People’s Republic of China
⨯

Feedback Regulations of miR-21 and MAPKs via Pdcd4 and Spry1 Are Involved in Arsenite-Induced Cell Malignant Transformation

Lu Shen,
Min Ling,
Yuan Li,
Yuan Xu,
Yun Zhou,
Jing Ye,
Ying Pang,
Yue Zhao,
Rongrong Jiang,
Jianping Zhang

Published: March 1, 2013
https://doi.org/10.1371/journal.pone.0057652

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