Developmental Fluoxetine Exposure Normalizes the Long-Term Effects of Maternal Stress on Post-Operative Pain in Sprague-Dawley Rat Offspring

Liesbeth Knaepen; Ine Rayen; Thierry D. Charlier; Marianne Fillet; Virginie Houbart; Maarten van Kleef; Harry W. Steinbusch; Jacob Patijn; Dick Tibboel; Elbert A. Joosten; Jodi L. Pawluski

doi:10.1371/journal.pone.0057608

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Open Access

Peer-reviewed

Research Article

Developmental Fluoxetine Exposure Normalizes the Long-Term Effects of Maternal Stress on Post-Operative Pain in Sprague-Dawley Rat Offspring

Liesbeth Knaepen,

Affiliation University Pain Center Maastricht, Department of Anesthesiology/Pain Management, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Ine Rayen,

Affiliation School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
⨯
Thierry D. Charlier,

Affiliation University of Liege, GIGA-Neurosciences, Liège, Belgium
⨯
Marianne Fillet,

Affiliation Laboratory of Analytical Pharmaceutical Chemistry, Department of Pharmacy, CIRM, University of Liège, Liège, Belgium
⨯
Virginie Houbart,

Affiliation Laboratory of Analytical Pharmaceutical Chemistry, Department of Pharmacy, CIRM, University of Liège, Liège, Belgium
⨯
Maarten van Kleef,

Affiliation University Pain Center Maastricht, Department of Anesthesiology/Pain Management, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Harry W. Steinbusch,

Affiliation School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
⨯
Jacob Patijn,

Affiliation University Pain Center Maastricht, Department of Anesthesiology/Pain Management, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Dick Tibboel,

Affiliation University of Liege, GIGA-Neurosciences, Liège, Belgium
⨯
Elbert A. Joosten,

Affiliation University Pain Center Maastricht, Department of Anesthesiology/Pain Management, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Jodi L. Pawluski

* E-mail: j.pawluski@ulg.ac.be

Affiliations School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands, University of Liege, GIGA-Neurosciences, Liège, Belgium
⨯

Developmental Fluoxetine Exposure Normalizes the Long-Term Effects of Maternal Stress on Post-Operative Pain in Sprague-Dawley Rat Offspring

Liesbeth Knaepen,
Ine Rayen,
Thierry D. Charlier,
Marianne Fillet,
Virginie Houbart,
Maarten van Kleef,
Harry W. Steinbusch,
Jacob Patijn,
Dick Tibboel,
Elbert A. Joosten

Published: February 21, 2013
https://doi.org/10.1371/journal.pone.0057608

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