Insulin-Stimulated Degradation of Apolipoprotein B100: Roles of Class II Phosphatidylinositol-3-Kinase and Autophagy

Ursula Andreo; Liang Guo; Doru V. Chirieac; Ana C. Tuyama; Emilie Montenont; Jeffrey L. Brodsky; Edward A. Fisher

doi:10.1371/journal.pone.0057590

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Peer-reviewed

Research Article

Insulin-Stimulated Degradation of Apolipoprotein B100: Roles of Class II Phosphatidylinositol-3-Kinase and Autophagy

Ursula Andreo ,

Contributed equally to this work with: Ursula Andreo, Liang Guo

Affiliation Department of Medicine (Cardiology) and the Marc and Ruti Bell Program in Vascular Biology; and the Department of Cell Biology, New York University School of Medicine, New York, New York, United States of America
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Liang Guo ,

Contributed equally to this work with: Ursula Andreo, Liang Guo

Affiliation Department of Medicine (Cardiology) and the Marc and Ruti Bell Program in Vascular Biology; and the Department of Cell Biology, New York University School of Medicine, New York, New York, United States of America
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Doru V. Chirieac,

Affiliation Department of Medicine (Cardiology) and the Marc and Ruti Bell Program in Vascular Biology; and the Department of Cell Biology, New York University School of Medicine, New York, New York, United States of America
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Ana C. Tuyama,

Affiliations Department of Medicine (Cardiology) and the Marc and Ruti Bell Program in Vascular Biology; and the Department of Cell Biology, New York University School of Medicine, New York, New York, United States of America, Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, New York, United States of America
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Emilie Montenont,

Affiliation Department of Medicine (Cardiology) and the Marc and Ruti Bell Program in Vascular Biology; and the Department of Cell Biology, New York University School of Medicine, New York, New York, United States of America
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Jeffrey L. Brodsky,

Affiliation Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Edward A. Fisher

* E-mail: edward.fisher@nyumc.org

Affiliation Department of Medicine (Cardiology) and the Marc and Ruti Bell Program in Vascular Biology; and the Department of Cell Biology, New York University School of Medicine, New York, New York, United States of America
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Insulin-Stimulated Degradation of Apolipoprotein B100: Roles of Class II Phosphatidylinositol-3-Kinase and Autophagy

Ursula Andreo,
Liang Guo,
Doru V. Chirieac,
Ana C. Tuyama,
Emilie Montenont,
Jeffrey L. Brodsky,
Edward A. Fisher

Published: March 13, 2013
https://doi.org/10.1371/journal.pone.0057590

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Hepatocytes
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Insulin
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Autophagic cell death
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Small interfering RNA
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Lipids
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Lipoprotein secretion
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Transfection
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Lipoproteins
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