In Vivo Knockdown of TAK1 Accelerates Bone Marrow Proliferation/Differentiation and Induces Systemic Inflammation

Paul M. Vink; Wendy M. Smout; Lilian J. Driessen-Engels; Alex M. de Bruin; Dianne Delsing; Magda A. Krajnc-Franken; Aswin J. Jansen; Eric F. Rovers; André A. van Puijenbroek; Allard Kaptein; Martijn A. Nolte; Anja Garritsen; Hans van Eenennaam

doi:10.1371/journal.pone.0057348

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Open Access

Peer-reviewed

Research Article

In Vivo Knockdown of TAK1 Accelerates Bone Marrow Proliferation/Differentiation and Induces Systemic Inflammation

Paul M. Vink,

Affiliation Department of Immune Therapeutics, Merck Research Laboratories, MSD, Oss, The Netherlands
⨯
Wendy M. Smout,

Affiliation Department of Immune Therapeutics, Merck Research Laboratories, MSD, Oss, The Netherlands
⨯
Lilian J. Driessen-Engels,

Affiliation Department of Immune Therapeutics, Merck Research Laboratories, MSD, Oss, The Netherlands
⨯
Alex M. de Bruin,

Affiliation Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
⨯
Dianne Delsing,

Affiliation Department of Immune Therapeutics, Merck Research Laboratories, MSD, Oss, The Netherlands
⨯
Magda A. Krajnc-Franken,

Affiliation Department of Toxicology and Drug Disposition, Merck Research Laboratories, MSD, Oss, The Netherlands
⨯
Aswin J. Jansen,

Affiliation Department of Immune Therapeutics, Merck Research Laboratories, MSD, Oss, The Netherlands
⨯
Eric F. Rovers,

Affiliation Department of Immune Therapeutics, Merck Research Laboratories, MSD, Oss, The Netherlands
⨯
André A. van Puijenbroek,

Affiliation Department of Immune Therapeutics, Merck Research Laboratories, MSD, Oss, The Netherlands
⨯
Allard Kaptein,

Affiliation Department of Molecular Pharmacology and DMPK, Merck Research Laboratories, MSD, Oss, The Netherlands
⨯
Martijn A. Nolte,

Affiliations Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands, Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands
⨯
Anja Garritsen,

Affiliation Department of Immune Therapeutics, Merck Research Laboratories, MSD, Oss, The Netherlands
⨯
Hans van Eenennaam

* E-mail: h.vaneenennaam@bionovion.com

Affiliation Department of Immune Therapeutics, Merck Research Laboratories, MSD, Oss, The Netherlands
⨯

In Vivo Knockdown of TAK1 Accelerates Bone Marrow Proliferation/Differentiation and Induces Systemic Inflammation

Paul M. Vink,
Wendy M. Smout,
Lilian J. Driessen-Engels,
Alex M. de Bruin,
Dianne Delsing,
Magda A. Krajnc-Franken,
Aswin J. Jansen,
Eric F. Rovers,
André A. van Puijenbroek,
Allard Kaptein

Published: March 7, 2013
https://doi.org/10.1371/journal.pone.0057348

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