Selection of an Aptamer Antidote to the Anticoagulant Drug Bivalirudin

Jennifer A. Martin; Parag Parekh; Youngmi Kim; Timothy E. Morey; Kwame Sefah; Nikolaus Gravenstein; Donn M. Dennis; Weihong Tan

doi:10.1371/journal.pone.0057341

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Open Access

Peer-reviewed

Research Article

Selection of an Aptamer Antidote to the Anticoagulant Drug Bivalirudin

Jennifer A. Martin,

Affiliation Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center and Center for Research at the Bio/nano Interface, University of Florida, Gainesville, Florida, United States of America
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Parag Parekh,

Affiliation Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center and Center for Research at the Bio/nano Interface, University of Florida, Gainesville, Florida, United States of America
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Youngmi Kim,

Affiliation Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center and Center for Research at the Bio/nano Interface, University of Florida, Gainesville, Florida, United States of America
⨯
Timothy E. Morey,

Affiliation Department of Anesthesiology and Pharmacology, University of Florida, Gainesville, Florida, United States of America
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Kwame Sefah,

Affiliation Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center and Center for Research at the Bio/nano Interface, University of Florida, Gainesville, Florida, United States of America
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Nikolaus Gravenstein,

Affiliation Department of Anesthesiology and Pharmacology, University of Florida, Gainesville, Florida, United States of America
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Donn M. Dennis,

Affiliation Department of Anesthesiology and Pharmacology, University of Florida, Gainesville, Florida, United States of America
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Weihong Tan

* E-mail: tan@chem.ufl.edu

Affiliation Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center and Center for Research at the Bio/nano Interface, University of Florida, Gainesville, Florida, United States of America
⨯

Selection of an Aptamer Antidote to the Anticoagulant Drug Bivalirudin

Jennifer A. Martin,
Parag Parekh,
Youngmi Kim,
Timothy E. Morey,
Kwame Sefah,
Nikolaus Gravenstein,
Donn M. Dennis,
Weihong Tan

Published: March 6, 2013
https://doi.org/10.1371/journal.pone.0057341

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09 Apr 2013
13:19 GMT
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Clarification of clotting time and bivalirudin concentration in clotting study Posted by PriscillaMStevens on 09 Apr 2013 at 13:19 GMT

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Antidotes
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Polymerase chain reaction
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Anticoagulants
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Heparin
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