Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

Edward Coulstock; Jane Sosabowski; Milan Ovečka; Rob Prince; Laura Goodall; Clare Mudd; Armin Sepp; Marie Davies; Julie Foster; Jerome Burnet; Gráinne Dunlevy; Adam Walker

doi:10.1371/journal.pone.0057263

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Open Access

Peer-reviewed

Research Article

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

Edward Coulstock,

Affiliation Innovation Biopharm Discovery Unit, Biopharm R&D, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Jane Sosabowski,

Affiliation Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⨯
Milan Ovečka,

Affiliation Innovation Biopharm Discovery Unit, Biopharm R&D, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Rob Prince,

Affiliation Innovation Biopharm Discovery Unit, Biopharm R&D, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Laura Goodall,

Affiliation Innovation Biopharm Discovery Unit, Biopharm R&D, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Clare Mudd,

Current address: Horizon Discovery Ltd., Cambridge, United Kingdom

Affiliation Innovation Biopharm Discovery Unit, Biopharm R&D, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Armin Sepp,

Affiliation Innovation Biopharm Discovery Unit, Biopharm R&D, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Marie Davies,

Affiliation Innovation Biopharm Discovery Unit, Biopharm R&D, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Julie Foster,

Affiliation Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⨯
Jerome Burnet,

Affiliation Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⨯
Gráinne Dunlevy,

Affiliation Innovation Biopharm Discovery Unit, Biopharm R&D, GlaxoSmithKline, Cambridge, United Kingdom
⨯
Adam Walker

* E-mail: adam.z.walker@gsk.com

Affiliation Innovation Biopharm Discovery Unit, Biopharm R&D, GlaxoSmithKline, Cambridge, United Kingdom
⨯

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

Edward Coulstock,
Jane Sosabowski,
Milan Ovečka,
Rob Prince,
Laura Goodall,
Clare Mudd,
Armin Sepp,
Marie Davies,
Julie Foster,
Jerome Burnet

Published: February 25, 2013
https://doi.org/10.1371/journal.pone.0057263

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Radiolabeling
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Cell fusion
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