Integration of HPV6 and Downregulation of AKR1C3 Expression Mark Malignant Transformation in a Patient with Juvenile-Onset Laryngeal Papillomatosis

• Christian Ulrich Huebbers ,

  Contributed equally to this work with: Christian Ulrich Huebbers, Simon Florian Preuss

  * E-mail: christian.huebbers@uni-koeln.de

  Affiliation Jean-Uhrmacher-Institute for Otorhinolaryngological Research, University of Cologne, Cologne, Germany

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• Simon Florian Preuss ,

  Contributed equally to this work with: Christian Ulrich Huebbers, Simon Florian Preuss

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Cologne, Cologne, Germany

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• Jutta Kolligs,

  Affiliation Jean-Uhrmacher-Institute for Otorhinolaryngological Research, University of Cologne, Cologne, Germany

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• Julia Vent,

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Cologne, Cologne, Germany

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• Markus Stenner,

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Cologne, Cologne, Germany

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• Ulrike Wieland,

  Affiliation Institute of Virology, National Reference Centre for Papilloma- and Polyomaviruses, University Hospital of Cologne, Cologne, Germany

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• Steffi Silling,

  Affiliation Institute of Virology, National Reference Centre for Papilloma- and Polyomaviruses, University Hospital of Cologne, Cologne, Germany

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• Uta Drebber,

  Affiliation Institute for Pathology, University Hospital of Cologne, Cologne, Germany

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• Ernst-Jan M. Speel ,

  ¶These authors also contributed equally to this work.

  Affiliation Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands

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• Jens Peter Klussmann

  ¶These authors also contributed equally to this work.

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Giessen, Giessen, Germany

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