A cis-Acting Element Present within the gag Open Reading Frame Negatively Impacts on the Activity of the HIV-1 IRES

Fernando Valiente-Echeverría; Maricarmen Vallejos; Anne Monette; Karla Pino; Alejandro Letelier; J. Pablo Huidobro-Toro; Andrew J. Mouland; Marcelo López-Lastra

doi:10.1371/journal.pone.0056962

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Peer-reviewed

Research Article

A cis-Acting Element Present within the gag Open Reading Frame Negatively Impacts on the Activity of the HIV-1 IRES

Fernando Valiente-Echeverría,

Affiliation Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
⨯
Maricarmen Vallejos,

Affiliation Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
⨯
Anne Monette,

Affiliations HIV-1 Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montréal, Québec, Canada, Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada
⨯
Karla Pino,

Affiliation Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
⨯
Alejandro Letelier,

Affiliation Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
⨯
J. Pablo Huidobro-Toro,

Affiliation Departamento de Fisiología, Centro de Envejecimiento y Regeneración, CARE, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
⨯
Andrew J. Mouland,

Affiliations HIV-1 Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montréal, Québec, Canada, Department of Experimental Medicine, McGill University, Montreal, Quebec, Canada, Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
⨯
Marcelo López-Lastra

* E-mail: malopez@med.puc.cl

Affiliation Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
⨯

A cis-Acting Element Present within the gag Open Reading Frame Negatively Impacts on the Activity of the HIV-1 IRES

Fernando Valiente-Echeverría,
Maricarmen Vallejos,
Anne Monette,
Karla Pino,
Alejandro Letelier,
J. Pablo Huidobro-Toro,
Andrew J. Mouland,
Marcelo López-Lastra

Published: February 25, 2013
https://doi.org/10.1371/journal.pone.0056962

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Internal ribosome entry site
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Messenger RNA
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Translation initiation
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Protein translation
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Plasmid construction
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