Bortezomib Reduces the Tumorigenicity of Multiple Myeloma via Downregulation of Upregulated Targets in Clonogenic Side Population Cells

Miho Nara; Kazuaki Teshima; Atsushi Watanabe; Mitsugu Ito; Keiko Iwamoto; Atsushi Kitabayashi; Masaaki Kume; Yoshiaki Hatano; Naoto Takahashi; Shinsuke Iida; Kenichi Sawada; Hiroyuki Tagawa

doi:10.1371/journal.pone.0056954

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Open Access

Peer-reviewed

Research Article

Bortezomib Reduces the Tumorigenicity of Multiple Myeloma via Downregulation of Upregulated Targets in Clonogenic Side Population Cells

Miho Nara,

Affiliation Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
⨯
Kazuaki Teshima,

Affiliation Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
⨯
Atsushi Watanabe,

Affiliation Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
⨯
Mitsugu Ito,

Affiliation Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
⨯
Keiko Iwamoto,

Affiliation Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
⨯
Atsushi Kitabayashi,

Affiliation Department of Internal Medicine, Akita Kumiai General Hospital, Akita, Japan
⨯
Masaaki Kume,

Affiliation Department of Internal Medicine, Hiraka General Hospital, Yokote, Japan
⨯
Yoshiaki Hatano,

Affiliation Department of Internal Medicine, Yamamoto Kumiai General Hospital, Noshiro, Japan
⨯
Naoto Takahashi,

Affiliation Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
⨯
Shinsuke Iida,

Affiliation Department of Medical Oncology and Immunology, Nagoya City University School of Medical Science, Nagoya, Japan
⨯
Kenichi Sawada,

Affiliation Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
⨯
Hiroyuki Tagawa

* E-mail: htagawa0279jp@yahoo.co.jp

Affiliation Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
⨯

Bortezomib Reduces the Tumorigenicity of Multiple Myeloma via Downregulation of Upregulated Targets in Clonogenic Side Population Cells

Miho Nara,
Kazuaki Teshima,
Atsushi Watanabe,
Mitsugu Ito,
Keiko Iwamoto,
Atsushi Kitabayashi,
Masaaki Kume,
Yoshiaki Hatano,
Naoto Takahashi,
Shinsuke Iida

Published: March 4, 2013
https://doi.org/10.1371/journal.pone.0056954

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Multiple myeloma
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Cancers and neoplasms
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Myeloma cells
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