The Selective Phosphodiesterase 4 Inhibitor Roflumilast and Phosphodiesterase 3/4 Inhibitor Pumafentrine Reduce Clinical Score and TNF Expression in Experimental Colitis in Mice

• Florian Rieder ,

  Contributed equally to this work with: Florian Rieder, Britta Siegmund

  Affiliations Division of Clinical Pharmacology and Section of Gastroenterology, University of Munich, Munich, Germany, Department of Internal Medicine I, University of Regensburg, Regensburg, Germany

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• Britta Siegmund ,

  Contributed equally to this work with: Florian Rieder, Britta Siegmund

  Affiliations Division of Clinical Pharmacology and Section of Gastroenterology, University of Munich, Munich, Germany, Medical Department I, Charité Universitätsmedizin, Campus Benjamin Franklin, Berlin, Germany

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• Daniela S. Bundschuh,

  Affiliation Takeda Pharmaceuticals International GmbH, Zurich, Switzerland

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• Hans-Anton Lehr,

  Affiliation Institut Universitaire de Pathologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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• Stefan Endres,

  Affiliation Division of Clinical Pharmacology and Section of Gastroenterology, University of Munich, Munich, Germany

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• Andreas Eigler

  * E-mail: andreas.eigler@med.uni-muenchen.de

  Affiliation Division of Clinical Pharmacology and Section of Gastroenterology, University of Munich, Munich, Germany

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