Co-Introduced Functional CCR2 Potentiates In Vivo Anti-Lung Cancer Functionality Mediated by T Cells Double Gene-Modified to Express WT1-Specific T-Cell Receptor

Hiroaki Asai; Hiroshi Fujiwara; Jun An; Toshiki Ochi; Yukihiro Miyazaki; Kozo Nagai; Sachiko Okamoto; Junichi Mineno; Kiyotaka Kuzushima; Hiroshi Shiku; Hirofumi Inoue; Masaki Yasukawa

doi:10.1371/journal.pone.0056820

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Open Access

Peer-reviewed

Research Article

Co-Introduced Functional CCR2 Potentiates In Vivo Anti-Lung Cancer Functionality Mediated by T Cells Double Gene-Modified to Express WT1-Specific T-Cell Receptor

Hiroaki Asai,

Affiliation Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
⨯
Hiroshi Fujiwara ,

* E-mail: yunarief@m.ehime-u.ac.jp (HF); yasukawa@m.ehime-u.ac.jp (MY)

Affiliations Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Ehime, Japan, Department of Cell Growth and Tumor Regulation, Ehime University Proteo-Medicine Research Center, Ehime, Japan
⨯
Jun An,

Affiliation Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
⨯
Toshiki Ochi,

Affiliations Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Ehime, Japan, Princess Margaret Hospital, Ontario Cancer Institute, Ontario, Canada
⨯
Yukihiro Miyazaki,

Affiliation Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
⨯
Kozo Nagai,

Affiliation Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan
⨯
Sachiko Okamoto,

Affiliation Center for Cell and Gene Therapy, Takara Bio Inc., Shiga, Japan
⨯
Junichi Mineno,

Affiliation Center for Cell and Gene Therapy, Takara Bio Inc., Shiga, Japan
⨯
Kiyotaka Kuzushima,

Affiliation Division of Immunology, Aichi Cancer Center, Aichi, Japan
⨯
Hiroshi Shiku,

Affiliation Department of Cancer Vaccine and Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan
⨯
Hirofumi Inoue,

Affiliation Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime, Japan
⨯
Masaki Yasukawa

* E-mail: yunarief@m.ehime-u.ac.jp (HF); yasukawa@m.ehime-u.ac.jp (MY)

Affiliations Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Ehime, Japan, Department of Cell Growth and Tumor Regulation, Ehime University Proteo-Medicine Research Center, Ehime, Japan
⨯

Co-Introduced Functional CCR2 Potentiates In Vivo Anti-Lung Cancer Functionality Mediated by T Cells Double Gene-Modified to Express WT1-Specific T-Cell Receptor

Hiroaki Asai,
Hiroshi Fujiwara,
Jun An,
Toshiki Ochi,
Yukihiro Miyazaki,
Kozo Nagai,
Sachiko Okamoto,
Junichi Mineno,
Kiyotaka Kuzushima,
Hiroshi Shiku

Published: February 18, 2013
https://doi.org/10.1371/journal.pone.0056820

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T cells
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Lung and intrathoracic tumors
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T cell receptors
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