High Heregulin Expression Is Associated with Activated HER3 and May Define an Actionable Biomarker in Patients with Squamous Cell Carcinomas of the Head and Neck

David S. Shames; Juliet Carbon; Kim Walter; Adrian M. Jubb; Cleopatra Kozlowski; Tom Januario; Do An; Ling Fu; Yuanyuan Xiao; Rajiv Raja; Brittany Jiang; Ashi Malekafzali; Howard Stern; Jeff Settleman; Timothy R. Wilson; Garret M. Hampton; Robert L. Yauch; Andrea Pirzkall; Lukas C. Amler

doi:10.1371/journal.pone.0056765

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Open Access

Peer-reviewed

Research Article

High Heregulin Expression Is Associated with Activated HER3 and May Define an Actionable Biomarker in Patients with Squamous Cell Carcinomas of the Head and Neck

David S. Shames ,

* E-mail: shames.david@gene.com (DSS); Amler.Lukas@gene.com (LCA)

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
Juliet Carbon,

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
Kim Walter,

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
Adrian M. Jubb,

Affiliation Research Pathology, Genentech Inc., South San Francisco, California, United States of America
⨯
Cleopatra Kozlowski,

Affiliation Safety Assessment Pathology, Genentech Inc., South San Francisco, California, United States of America
⨯
Tom Januario,

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
Do An,

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
Ling Fu,

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
Yuanyuan Xiao,

Affiliation Biostatistics, Genentech Inc., South San Francisco, California, United States of America
⨯
Rajiv Raja,

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
Brittany Jiang,

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
Ashi Malekafzali,

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
Howard Stern,

Affiliation Research Pathology, Genentech Inc., South San Francisco, California, United States of America
⨯
Jeff Settleman,

Affiliation Molecular Diagnostics and Cancer Cell Biology, Genentech Inc., South San Francisco, California, United States of America
⨯
Timothy R. Wilson,

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
Garret M. Hampton,

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
Robert L. Yauch,

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
Andrea Pirzkall,

Affiliation Early Clinical Development, Genentech Inc., South San Francisco, California, United States of America
⨯
[ ... ],
Lukas C. Amler

* E-mail: shames.david@gene.com (DSS); Amler.Lukas@gene.com (LCA)

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America
⨯
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High Heregulin Expression Is Associated with Activated HER3 and May Define an Actionable Biomarker in Patients with Squamous Cell Carcinomas of the Head and Neck

David S. Shames,
Juliet Carbon,
Kim Walter,
Adrian M. Jubb,
Cleopatra Kozlowski,
Tom Januario,
Do An,
Ling Fu,
Yuanyuan Xiao,
Rajiv Raja

Published: February 28, 2013
https://doi.org/10.1371/journal.pone.0056765

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