Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15null Mice, Leading to Protection against Type 1 Diabetes Development

Shamina M. Green-Mitchell; Sarah A. Tersey; Banumathi K. Cole; Kaiwen Ma; Norine S. Kuhn; Tina Duong Cunningham; Nelly A. Maybee; Swarup K. Chakrabarti; Marcia McDuffie; David A. Taylor-Fishwick; Raghavendra G. Mirmira; Jerry L. Nadler; Margaret A. Morris

doi:10.1371/journal.pone.0056763

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Research Article

Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15^null Mice, Leading to Protection against Type 1 Diabetes Development

Shamina M. Green-Mitchell,

Affiliation Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Sarah A. Tersey,

Affiliation Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Banumathi K. Cole,

Affiliation Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Kaiwen Ma,

Affiliation Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Norine S. Kuhn,

Affiliation Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Tina Duong Cunningham,

Affiliation Graduate Program in Public Health, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Nelly A. Maybee,

Affiliation Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Swarup K. Chakrabarti,

Affiliation Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Marcia McDuffie,

Affiliations Department of Microbiology, University of Virginia, Charlottesville, Virginia, United States of America, Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
⨯
David A. Taylor-Fishwick,

Affiliations Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, United States of America, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Raghavendra G. Mirmira,

Affiliation Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Jerry L. Nadler,

Affiliations Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, United States of America, Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Margaret A. Morris

* E-mail: morrisma@evms.edu

Affiliations Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, United States of America, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯

Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15^null Mice, Leading to Protection against Type 1 Diabetes Development

Shamina M. Green-Mitchell,
Sarah A. Tersey,
Banumathi K. Cole,
Kaiwen Ma,
Norine S. Kuhn,
Tina Duong Cunningham,
Nelly A. Maybee,
Swarup K. Chakrabarti,
Marcia McDuffie,
David A. Taylor-Fishwick

Published: February 21, 2013
https://doi.org/10.1371/journal.pone.0056763

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