MEPE-Derived ASARM Peptide Inhibits Odontogenic Differentiation of Dental Pulp Stem Cells and Impairs Mineralization in Tooth Models of X-Linked Hypophosphatemia

• Benjamin Salmon ,

  Contributed equally to this work with: Benjamin Salmon, Claire Bardet

  Affiliations EA 2496, Pathologies, Imaging and Biotherapies of the Tooth, UFR Odontologie, University Paris Descartes PRES Sorbonne Paris Cité, Montrouge, France, AP-HP Odontology Department Bretonneau – Louis Mourier, Hôpitaux Universitaires Paris Nord Val de Seine, Paris France, Centre de Référence des Maladies Rares du Métabolisme du Phosphore et du Calcium, AP-HP, Kremlin Bicêtre, France

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• Claire Bardet ,

  Contributed equally to this work with: Benjamin Salmon, Claire Bardet

  Affiliation EA 2496, Pathologies, Imaging and Biotherapies of the Tooth, UFR Odontologie, University Paris Descartes PRES Sorbonne Paris Cité, Montrouge, France

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• Mayssam Khaddam,

  Affiliation EA 2496, Pathologies, Imaging and Biotherapies of the Tooth, UFR Odontologie, University Paris Descartes PRES Sorbonne Paris Cité, Montrouge, France

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• Jiar Naji,

  Affiliation EA 2496, Pathologies, Imaging and Biotherapies of the Tooth, UFR Odontologie, University Paris Descartes PRES Sorbonne Paris Cité, Montrouge, France

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• Benjamin R. Coyac,

  Affiliations EA 2496, Pathologies, Imaging and Biotherapies of the Tooth, UFR Odontologie, University Paris Descartes PRES Sorbonne Paris Cité, Montrouge, France, AP-HP Odontology Department Bretonneau – Louis Mourier, Hôpitaux Universitaires Paris Nord Val de Seine, Paris France, Faculty of Dentistry, and Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada

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• Brigitte Baroukh,

  Affiliation EA 2496, Pathologies, Imaging and Biotherapies of the Tooth, UFR Odontologie, University Paris Descartes PRES Sorbonne Paris Cité, Montrouge, France

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• Franck Letourneur,

  Affiliation Institut Cochin, University Paris Descartes PRES Sorbonne Paris Cité, Paris, France

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• Julie Lesieur,

  Affiliation EA 2496, Pathologies, Imaging and Biotherapies of the Tooth, UFR Odontologie, University Paris Descartes PRES Sorbonne Paris Cité, Montrouge, France

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• Franck Decup,

  Affiliations EA 2496, Pathologies, Imaging and Biotherapies of the Tooth, UFR Odontologie, University Paris Descartes PRES Sorbonne Paris Cité, Montrouge, France, AP-HP Odontology Department Charles Foix, Ivry Sur Seine, France

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• Dominique Le Denmat,

  Affiliation EA 2496, Pathologies, Imaging and Biotherapies of the Tooth, UFR Odontologie, University Paris Descartes PRES Sorbonne Paris Cité, Montrouge, France

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• Antonino Nicoletti,

  Affiliations Inserm UMRS698, Paris, France, Denis Diderot University, UMRS698, Paris, France

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• Anne Poliard,

  Affiliation EA 2496, Pathologies, Imaging and Biotherapies of the Tooth, UFR Odontologie, University Paris Descartes PRES Sorbonne Paris Cité, Montrouge, France

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• Peter S. Rowe,

  Affiliation The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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• Eric Huet,

  Affiliation Université Paris-Est, Laboratoire CRRET, CNRS, Créteil, France

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• Sibylle Opsahl Vital,

  Affiliations EA 2496, Pathologies, Imaging and Biotherapies of the Tooth, UFR Odontologie, University Paris Descartes PRES Sorbonne Paris Cité, Montrouge, France, AP-HP Odontology Department Bretonneau – Louis Mourier, Hôpitaux Universitaires Paris Nord Val de Seine, Paris France, Centre de Référence des Maladies Rares du Métabolisme du Phosphore et du Calcium, AP-HP, Kremlin Bicêtre, France

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• Agnès Linglart,

  Affiliations Centre de Référence des Maladies Rares du Métabolisme du Phosphore et du Calcium, AP-HP, Kremlin Bicêtre, France, APHP Endocrinology and Diabetology for Children, Bicêtre Paris Sud Hospital, Kremlin Bicêtre, France, Université Paris-Sud, Kremlin Bicêtre, France

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• Marc D. McKee,

  Affiliation Faculty of Dentistry, and Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada

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•  [ ... ],
• Catherine Chaussain

  * E-mail: catherine.chaussain@parisdescartes.fr

  Affiliations EA 2496, Pathologies, Imaging and Biotherapies of the Tooth, UFR Odontologie, University Paris Descartes PRES Sorbonne Paris Cité, Montrouge, France, AP-HP Odontology Department Bretonneau – Louis Mourier, Hôpitaux Universitaires Paris Nord Val de Seine, Paris France, Centre de Référence des Maladies Rares du Métabolisme du Phosphore et du Calcium, AP-HP, Kremlin Bicêtre, France

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