Use of a Molecular Decoy to Segregate Transport from Antigenicity in the FrpB Iron Transporter from Neisseria meningitidis

Muhammad Saleem; Stephen M. Prince; Stephen E. J. Rigby; Muhammad Imran; Hema Patel; Hannah Chan; Holly Sanders; Martin C. J. Maiden; Ian M. Feavers; Jeremy P. Derrick

doi:10.1371/journal.pone.0056746

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Open Access

Peer-reviewed

Research Article

Use of a Molecular Decoy to Segregate Transport from Antigenicity in the FrpB Iron Transporter from Neisseria meningitidis

Muhammad Saleem,

Affiliation Michael Smith Building, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom
⨯
Stephen M. Prince,

Affiliation Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, United Kingdom
⨯
Stephen E. J. Rigby,

Affiliation Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, United Kingdom
⨯
Muhammad Imran,

Affiliation Michael Smith Building, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom
⨯
Hema Patel,

Affiliation National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, United Kingdom
⨯
Hannah Chan,

Affiliation National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, United Kingdom
⨯
Holly Sanders,

Affiliation National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, United Kingdom
⨯
Martin C. J. Maiden,

Affiliation Department of Zoology, University of Oxford, South Parks Road, Oxford, United Kingdom
⨯
Ian M. Feavers,

Affiliation National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, United Kingdom
⨯
Jeremy P. Derrick

* E-mail: Jeremy.Derrick@manchester.ac.uk

Affiliation Michael Smith Building, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom
⨯

Use of a Molecular Decoy to Segregate Transport from Antigenicity in the FrpB Iron Transporter from Neisseria meningitidis

Muhammad Saleem,
Stephen M. Prince,
Stephen E. J. Rigby,
Muhammad Imran,
Hema Patel,
Hannah Chan,
Holly Sanders,
Martin C. J. Maiden,
Ian M. Feavers,
Jeremy P. Derrick

Published: February 15, 2013
https://doi.org/10.1371/journal.pone.0056746

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Crystal structure
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Neisseria meningitidis
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Antigenic variation
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Heme
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Electron spin resonance spectroscopy
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Electron density
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Enzyme-linked immunoassays
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Outer membrane proteins
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