Changes in Muscle Cell Metabolism and Mechanotransduction Are Associated with Myopathic Phenotype in a Mouse Model of Collagen VI Deficiency

Sara De Palma; Roberta Leone; Paolo Grumati; Michele Vasso; Roman Polishchuk; Daniele Capitanio; Paola Braghetta; Paolo Bernardi; Paolo Bonaldo; Cecilia Gelfi

doi:10.1371/journal.pone.0056716

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Open Access

Peer-reviewed

Research Article

Changes in Muscle Cell Metabolism and Mechanotransduction Are Associated with Myopathic Phenotype in a Mouse Model of Collagen VI Deficiency

Sara De Palma,

Affiliations Department of Biomedical Sciences for Health, University of Milan, Segrate (MI), Italy, Institute of Molecular Bioimaging and Physiology, National Research Council (CNR), Segrate (MI), Italy
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Roberta Leone,

Affiliation Department of Biomedical Sciences for Health, University of Milan, Segrate (MI), Italy
⨯
Paolo Grumati,

Affiliation Department of Biomedical Sciences, University of Padova, Padova, Italy
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Michele Vasso,

Affiliations Department of Biomedical Sciences for Health, University of Milan, Segrate (MI), Italy, Institute of Molecular Bioimaging and Physiology, National Research Council (CNR), Segrate (MI), Italy
⨯
Roman Polishchuk,

Affiliation Telethon Institute of Genetics and Medicine, Institute of Protein Biochemistry, Italian National Research Council (CNR), Naples, Italy
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Daniele Capitanio,

Affiliation Department of Biomedical Sciences for Health, University of Milan, Segrate (MI), Italy
⨯
Paola Braghetta,

Affiliation Department of Biomedical Sciences, University of Padova, Padova, Italy
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Paolo Bernardi,

Affiliation Department of Biomedical Sciences, University of Padova, Padova, Italy
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Paolo Bonaldo,

Affiliation Department of Biomedical Sciences, University of Padova, Padova, Italy
⨯
Cecilia Gelfi

* E-mail: cecilia.gelfi@unimi.it

Affiliations Department of Biomedical Sciences for Health, University of Milan, Segrate (MI), Italy, Institute of Molecular Bioimaging and Physiology, National Research Council (CNR), Segrate (MI), Italy
⨯

Changes in Muscle Cell Metabolism and Mechanotransduction Are Associated with Myopathic Phenotype in a Mouse Model of Collagen VI Deficiency

Sara De Palma,
Roberta Leone,
Paolo Grumati,
Michele Vasso,
Roman Polishchuk,
Daniele Capitanio,
Paola Braghetta,
Paolo Bernardi,
Paolo Bonaldo,
Cecilia Gelfi

Published: February 20, 2013
https://doi.org/10.1371/journal.pone.0056716

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Muscle proteins
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Thoracic diaphragm
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Gastrocnemius muscles
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Collagens
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Protein metabolism
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Proteomics
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Citric acid cycle
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