A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease

Masashi Kitagawa; Hitoshi Sugiyama; Hiroshi Morinaga; Tatsuyuki Inoue; Keiichi Takiue; Ayu Ogawa; Toshio Yamanari; Yoko Kikumoto; Haruhito Adam Uchida; Shinji Kitamura; Yohei Maeshima; Kazufumi Nakamura; Hiroshi Ito; Hirofumi Makino

doi:10.1371/journal.pone.0056695

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Open Access

Peer-reviewed

Research Article

A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease

Masashi Kitagawa,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hitoshi Sugiyama ,

* E-mail: hitoshis@md.okayama-u.ac.jp

Affiliations Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Department of Chronic Kidney Disease and Peritoneal Dialysis, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hiroshi Morinaga,

Affiliations Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Department of Chronic Kidney Disease and Peritoneal Dialysis, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Tatsuyuki Inoue,

Current address: Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Keiichi Takiue,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Ayu Ogawa,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Toshio Yamanari,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Yoko Kikumoto,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Haruhito Adam Uchida,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Shinji Kitamura,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Yohei Maeshima,

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Kazufumi Nakamura,

Affiliation Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hiroshi Ito,

Affiliation Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hirofumi Makino

Affiliation Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯

A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease

Masashi Kitagawa,
Hitoshi Sugiyama,
Hiroshi Morinaga,
Tatsuyuki Inoue,
Keiichi Takiue,
Ayu Ogawa,
Toshio Yamanari,
Yoko Kikumoto,
Haruhito Adam Uchida,
Shinji Kitamura

Published: February 19, 2013
https://doi.org/10.1371/journal.pone.0056695

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Calcification
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