SGLT5 Reabsorbs Fructose in the Kidney but Its Deficiency Paradoxically Exacerbates Hepatic Steatosis Induced by Fructose

Taku Fukuzawa; Masanori Fukazawa; Otoya Ueda; Hideaki Shimada; Aki Kito; Mami Kakefuda; Yosuke Kawase; Naoko A. Wada; Chisato Goto; Naoshi Fukushima; Kou-ichi Jishage; Kiyofumi Honda; George L. King; Yoshiki Kawabe

doi:10.1371/journal.pone.0056681

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Open Access

Peer-reviewed

Research Article

SGLT5 Reabsorbs Fructose in the Kidney but Its Deficiency Paradoxically Exacerbates Hepatic Steatosis Induced by Fructose

Taku Fukuzawa,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Masanori Fukazawa ,

* E-mail: fukazawamsn@chugai-pharm.co.jp

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Otoya Ueda,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Hideaki Shimada,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Aki Kito,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Mami Kakefuda,

Affiliation Chugai Research Institute for Medical Science, Inc., Gotemba, Shizuoka, Japan
⨯
Yosuke Kawase,

Affiliation Chugai Research Institute for Medical Science, Inc., Gotemba, Shizuoka, Japan
⨯
Naoko A. Wada,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Chisato Goto,

Affiliation Chugai Research Institute for Medical Science, Inc., Gotemba, Shizuoka, Japan
⨯
Naoshi Fukushima,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Kou-ichi Jishage,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Kiyofumi Honda,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
George L. King,

Affiliation Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Yoshiki Kawabe

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯

SGLT5 Reabsorbs Fructose in the Kidney but Its Deficiency Paradoxically Exacerbates Hepatic Steatosis Induced by Fructose

Taku Fukuzawa,
Masanori Fukazawa,
Otoya Ueda,
Hideaki Shimada,
Aki Kito,
Mami Kakefuda,
Yosuke Kawase,
Naoko A. Wada,
Chisato Goto,
Naoshi Fukushima

Published: February 25, 2013
https://doi.org/10.1371/journal.pone.0056681

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