Epithelial–Mesenchymal Transition (EMT) Induced by TNF-α Requires AKT/GSK-3β-Mediated Stabilization of Snail in Colorectal Cancer

Hao Wang; Hong-Sheng Wang; Bin-Hua Zhou; Cui-Lin Li; Fan Zhang; Xian-Feng Wang; Ge Zhang; Xian-Zhang Bu; Shao-Hui Cai; Jun Du

doi:10.1371/journal.pone.0056664

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Open Access

Peer-reviewed

Research Article

Epithelial–Mesenchymal Transition (EMT) Induced by TNF-α Requires AKT/GSK-3β-Mediated Stabilization of Snail in Colorectal Cancer

Hao Wang,

Affiliation Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Hong-Sheng Wang,

Affiliation Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Bin-Hua Zhou,

Affiliation Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Cui-Lin Li,

Affiliation Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Fan Zhang,

Affiliation Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Xian-Feng Wang,

Affiliation Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Ge Zhang,

Affiliation Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Xian-Zhang Bu,

Affiliation Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Shao-Hui Cai ,

* E-mail: dujun@mail.sysu.edu.cn (JD); csh5689@sina.com (SHC)

Affiliation Department of Pharmacology, College of Pharmacy, Jinan University, Guangzhou, China
⨯
Jun Du

* E-mail: dujun@mail.sysu.edu.cn (JD); csh5689@sina.com (SHC)

Affiliation Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯

Epithelial–Mesenchymal Transition (EMT) Induced by TNF-α Requires AKT/GSK-3β-Mediated Stabilization of Snail in Colorectal Cancer

Hao Wang,
Hong-Sheng Wang,
Bin-Hua Zhou,
Cui-Lin Li,
Fan Zhang,
Xian-Feng Wang,
Ge Zhang,
Xian-Zhang Bu,
Shao-Hui Cai,
Jun Du

Published: February 19, 2013
https://doi.org/10.1371/journal.pone.0056664

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