Holothurian Glycosaminoglycan Inhibits Metastasis and Thrombosis via Targeting of Nuclear Factor-κB/Tissue Factor/Factor Xa Pathway in Melanoma B16F10 Cells

Yang Zhao; Daohai Zhang; Sheng Wang; Li Tao; Aiyun Wang; Wenxing Chen; Zhijie Zhu; Shizhong Zheng; Xiang Gao; Yin Lu

doi:10.1371/journal.pone.0056557

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Open Access

Peer-reviewed

Research Article

Holothurian Glycosaminoglycan Inhibits Metastasis and Thrombosis via Targeting of Nuclear Factor-κB/Tissue Factor/Factor Xa Pathway in Melanoma B16F10 Cells

Yang Zhao,

Affiliation Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China
⨯
Daohai Zhang,

Affiliation Department of Pathology, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia
⨯
Sheng Wang,

Affiliation Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China
⨯
Li Tao,

Affiliation Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China
⨯
Aiyun Wang,

Affiliation Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China
⨯
Wenxing Chen,

Affiliation Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China
⨯
Zhijie Zhu,

Affiliation Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China
⨯
Shizhong Zheng,

Affiliations Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China, Jiangsu Key Laboratory of Efficacy and Safety Evaluation of Traditional Chinese Medicine, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China
⨯
Xiang Gao,

Affiliation Model Animal Research Center of Nanjing University, Nanjing, People’s Republic of China
⨯
Yin Lu

* E-mail: profyinlu@163.com

Affiliations Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China, Jiangsu Key Laboratory of Efficacy and Safety Evaluation of Traditional Chinese Medicine, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China
⨯

Holothurian Glycosaminoglycan Inhibits Metastasis and Thrombosis via Targeting of Nuclear Factor-κB/Tissue Factor/Factor Xa Pathway in Melanoma B16F10 Cells

Yang Zhao,
Daohai Zhang,
Sheng Wang,
Li Tao,
Aiyun Wang,
Wenxing Chen,
Zhijie Zhu,
Shizhong Zheng,
Xiang Gao,
Yin Lu

Published: February 21, 2013
https://doi.org/10.1371/journal.pone.0056557

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