Morphological and Metabolic Changes in the Nigro-Striatal Pathway of Synthetic Proteasome Inhibitor (PSI)-Treated Rats: A MRI and MRS Study

Stefano Delli Pizzi; Cosmo Rossi; Vincenzo Di Matteo; Ennio Esposito; Simone Guarnieri; Maria Addolorata Mariggiò; Raffaella Franciotti; Massimo Caulo; Astrid Thomas; Marco Onofrj; Armando Tartaro; Laura Bonanni

doi:10.1371/journal.pone.0056501

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Open Access

Peer-reviewed

Research Article

Morphological and Metabolic Changes in the Nigro-Striatal Pathway of Synthetic Proteasome Inhibitor (PSI)-Treated Rats: A MRI and MRS Study

Stefano Delli Pizzi,

Affiliations ITAB, “G. D’Annunzio University”, Chieti, Italy, Department of Neuroscience and Imaging and CE.S.I. Aging Research Center, University G.d’Annunzio of Chieti-Pescara, Italy
⨯
Cosmo Rossi,

Affiliation Aging Research Center, Ce.S.I., “Gabriele d’Annunzio” University Foundation, Chieti, Italy
⨯
Vincenzo Di Matteo,

Affiliation Laboratory of Neurophysiology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro (Chieti), Italy
⨯
Ennio Esposito,

Affiliation Laboratory of Neurophysiology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro (Chieti), Italy
⨯
Simone Guarnieri,

Affiliation Department of Neuroscience and Imaging and CE.S.I. Aging Research Center, University G.d’Annunzio of Chieti-Pescara, Italy
⨯
Maria Addolorata Mariggiò,

Affiliation Department of Neuroscience and Imaging and CE.S.I. Aging Research Center, University G.d’Annunzio of Chieti-Pescara, Italy
⨯
Raffaella Franciotti,

Affiliation ITAB, “G. D’Annunzio University”, Chieti, Italy
⨯
Massimo Caulo,

Affiliations ITAB, “G. D’Annunzio University”, Chieti, Italy, Department of Neuroscience and Imaging and CE.S.I. Aging Research Center, University G.d’Annunzio of Chieti-Pescara, Italy
⨯
Astrid Thomas,

Affiliation Department of Neuroscience and Imaging and CE.S.I. Aging Research Center, University G.d’Annunzio of Chieti-Pescara, Italy
⨯
Marco Onofrj,

Affiliation Department of Neuroscience and Imaging and CE.S.I. Aging Research Center, University G.d’Annunzio of Chieti-Pescara, Italy
⨯
Armando Tartaro ,

Contributed equally to this work with: Armando Tartaro, Laura Bonanni

Affiliations ITAB, “G. D’Annunzio University”, Chieti, Italy, Department of Neuroscience and Imaging and CE.S.I. Aging Research Center, University G.d’Annunzio of Chieti-Pescara, Italy
⨯
Laura Bonanni

Contributed equally to this work with: Armando Tartaro, Laura Bonanni

* E-mail: l.bonanni@unich.it

Affiliation Department of Neuroscience and Imaging and CE.S.I. Aging Research Center, University G.d’Annunzio of Chieti-Pescara, Italy
⨯

Morphological and Metabolic Changes in the Nigro-Striatal Pathway of Synthetic Proteasome Inhibitor (PSI)-Treated Rats: A MRI and MRS Study

Stefano Delli Pizzi,
Cosmo Rossi,
Vincenzo Di Matteo,
Ennio Esposito,
Simone Guarnieri,
Maria Addolorata Mariggiò,
Raffaella Franciotti,
Massimo Caulo,
Astrid Thomas,
Marco Onofrj

Published: February 19, 2013
https://doi.org/10.1371/journal.pone.0056501

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