Conformational and Thermal Stability Improvements for the Large-Scale Production of Yeast-Derived Rabbit Hemorrhagic Disease Virus-Like Particles as Multipurpose Vaccine

Erlinda Fernández; Jorge R. Toledo; Lídice Méndez; Nemecio González; Francisco Parra; José M. Martín-Alonso; Miladys Limonta; Kosara Sánchez; Ania Cabrales; Mario P. Estrada; Alina Rodríguez-Mallón; Omar Farnós

doi:10.1371/journal.pone.0056417

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Open Access

Peer-reviewed

Research Article

Conformational and Thermal Stability Improvements for the Large-Scale Production of Yeast-Derived Rabbit Hemorrhagic Disease Virus-Like Particles as Multipurpose Vaccine

Erlinda Fernández ,

Contributed equally to this work with: Erlinda Fernández, Jorge R. Toledo

Affiliation Division of Animal Biotechnology, Center for Genetic Engineering and Biotechnology, Havana, Cuba
⨯
Jorge R. Toledo ,

Contributed equally to this work with: Erlinda Fernández, Jorge R. Toledo

Affiliation Department of Physiopathology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile
⨯
Lídice Méndez,

Affiliation Division of Animal Biotechnology, Center for Genetic Engineering and Biotechnology, Havana, Cuba
⨯
Nemecio González,

Affiliation Technological Development Department, Center for Genetic Engineering and Biotechnology of Camaguey, Camaguey, Cuba
⨯
Francisco Parra,

Affiliation Department of Biochemistry and Molecular Biology, Instituto Universitario de Biotecnología de Asturias, University of Oviedo, Oviedo, Spain
⨯
José M. Martín-Alonso,

Affiliation Department of Biochemistry and Molecular Biology, Instituto Universitario de Biotecnología de Asturias, University of Oviedo, Oviedo, Spain
⨯
Miladys Limonta,

Affiliation Division of Technological Development, Center for Genetic Engineering and Biotechnology, Havana, Cuba
⨯
Kosara Sánchez,

Affiliation Division of Development of Formulations, Center for Genetic Engineering and Biotechnology, Havana, Cuba
⨯
Ania Cabrales,

Affiliation Peptide Synthesis Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba
⨯
Mario P. Estrada,

Affiliation Division of Animal Biotechnology, Center for Genetic Engineering and Biotechnology, Havana, Cuba
⨯
Alina Rodríguez-Mallón,

Affiliation Division of Animal Biotechnology, Center for Genetic Engineering and Biotechnology, Havana, Cuba
⨯
Omar Farnós

* E-mail: omar.farnos@yahoo.com

Affiliation Division of Animal Biotechnology, Center for Genetic Engineering and Biotechnology, Havana, Cuba
⨯

Conformational and Thermal Stability Improvements for the Large-Scale Production of Yeast-Derived Rabbit Hemorrhagic Disease Virus-Like Particles as Multipurpose Vaccine

Erlinda Fernández,
Jorge R. Toledo,
Lídice Méndez,
Nemecio González,
Francisco Parra,
José M. Martín-Alonso,
Miladys Limonta,
Kosara Sánchez,
Ania Cabrales,
Mario P. Estrada

Published: February 27, 2013
https://doi.org/10.1371/journal.pone.0056417

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