EVI1 Inhibits Apoptosis Induced by Antileukemic Drugs via Upregulation of CDKN1A/p21/WAF in Human Myeloid Cells

Anna Rommer; Birgit Steinmetz; Friederike Herbst; Hubert Hackl; Petra Heffeter; Daniela Heilos; Martin Filipits; Katarina Steinleitner; Shayda Hemmati; Irene Herbacek; Ilse Schwarzinger; Katharina Hartl; Pieter Rondou; Hanno Glimm; Kadin Karakaya; Alwin Krämer; Walter Berger; Rotraud Wieser

doi:10.1371/journal.pone.0056308

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Open Access

Peer-reviewed

Research Article

EVI1 Inhibits Apoptosis Induced by Antileukemic Drugs via Upregulation of CDKN1A/p21/WAF in Human Myeloid Cells

Anna Rommer,

Affiliations Department of Medicine I, Medical University of Vienna, Vienna, Austria, Comprehensive Cancer Center of the Medical University of Vienna, Vienna, Austria
⨯
Birgit Steinmetz,

Affiliations Department of Medicine I, Medical University of Vienna, Vienna, Austria, Comprehensive Cancer Center of the Medical University of Vienna, Vienna, Austria
⨯
Friederike Herbst,

Affiliation Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany
⨯
Hubert Hackl,

Affiliation Division of Bioinformatics, Innsbruck Medical University, Innsbruck, Austria
⨯
Petra Heffeter,

Affiliations Comprehensive Cancer Center of the Medical University of Vienna, Vienna, Austria, Department of Medicine I, Institute of Cancer Research, and Research Platform “Translational Cancer Therapy Research”, Medical University of Vienna, Vienna, Austria
⨯
Daniela Heilos,

Affiliations Department of Medicine I, Medical University of Vienna, Vienna, Austria, Comprehensive Cancer Center of the Medical University of Vienna, Vienna, Austria
⨯
Martin Filipits,

Affiliations Comprehensive Cancer Center of the Medical University of Vienna, Vienna, Austria, Department of Medicine I, Institute of Cancer Research, and Research Platform “Translational Cancer Therapy Research”, Medical University of Vienna, Vienna, Austria
⨯
Katarina Steinleitner,

Affiliations Department of Medicine I, Medical University of Vienna, Vienna, Austria, Comprehensive Cancer Center of the Medical University of Vienna, Vienna, Austria
⨯
Shayda Hemmati,

Affiliation Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany
⨯
Irene Herbacek,

Affiliation Department of Medicine I, Institute of Cancer Research, and Research Platform “Translational Cancer Therapy Research”, Medical University of Vienna, Vienna, Austria
⨯
Ilse Schwarzinger,

Affiliation Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
⨯
Katharina Hartl,

Affiliations Department of Medicine I, Medical University of Vienna, Vienna, Austria, Comprehensive Cancer Center of the Medical University of Vienna, Vienna, Austria
⨯
Pieter Rondou,

Affiliation Center for Medical Genetics Ghent, Ghent University Hospital Medical Research Building, Ghent, Belgium
⨯
Hanno Glimm,

Affiliation Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany
⨯
Kadin Karakaya,

Affiliation Clinical Cooperation Unit Molecular Haematology/Oncology, German Cancer Research Center, Heidelberg, Germany
⨯
Alwin Krämer,

Affiliation Clinical Cooperation Unit Molecular Haematology/Oncology, German Cancer Research Center, Heidelberg, Germany
⨯
Walter Berger,

Affiliations Comprehensive Cancer Center of the Medical University of Vienna, Vienna, Austria, Department of Medicine I, Institute of Cancer Research, and Research Platform “Translational Cancer Therapy Research”, Medical University of Vienna, Vienna, Austria
⨯
[ ... ],
Rotraud Wieser

* E-mail: rotraud.wieser@meduniwien.ac.at

Affiliations Department of Medicine I, Medical University of Vienna, Vienna, Austria, Comprehensive Cancer Center of the Medical University of Vienna, Vienna, Austria
⨯
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EVI1 Inhibits Apoptosis Induced by Antileukemic Drugs via Upregulation of CDKN1A/p21/WAF in Human Myeloid Cells

Anna Rommer,
Birgit Steinmetz,
Friederike Herbst,
Hubert Hackl,
Petra Heffeter,
Daniela Heilos,
Martin Filipits,
Katarina Steinleitner,
Shayda Hemmati,
Irene Herbacek

Published: February 14, 2013
https://doi.org/10.1371/journal.pone.0056308

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13 Mar 2015
08:43 GMT
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GEO accession number Posted by rotraud on 13 Mar 2015 at 08:43 GMT

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Gene regulation
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Apoptosis
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Hyperexpression techniques
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Gene expression
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Acute myeloid leukemia
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