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Open Access

Peer-reviewed

Research Article

In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle

Satoshi Uchida,

Affiliation Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
⨯
Keiji Itaka ,

* E-mail: itaka-ort@umin.net (KI); kataoka@bmw.t.u-tokyo.ac.jp (KK)

Affiliation Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
⨯
Hirokuni Uchida,

Affiliation Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
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Kentaro Hayakawa,

Affiliation Department of Rehabilitation for the Movement Functions, Research Institute, National Rehabilitation Center for the Persons With Disabilities, Tokorozawa, Saitama, Japan
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Toru Ogata,

Affiliation Department of Rehabilitation for the Movement Functions, Research Institute, National Rehabilitation Center for the Persons With Disabilities, Tokorozawa, Saitama, Japan
⨯
Takehiko Ishii,

Affiliation Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
⨯
Shigeto Fukushima,

Affiliation Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
⨯
Kensuke Osada,

Affiliation Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
⨯
Kazunori Kataoka

* E-mail: itaka-ort@umin.net (KI); kataoka@bmw.t.u-tokyo.ac.jp (KK)

Affiliations Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
⨯

In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle

Satoshi Uchida,
Keiji Itaka,
Hirokuni Uchida,
Kentaro Hayakawa,
Toru Ogata,
Takehiko Ishii,
Shigeto Fukushima,
Kensuke Osada,
Kazunori Kataoka

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Published: February 13, 2013
https://doi.org/10.1371/journal.pone.0056220

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Messenger RNA
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Central nervous system
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Toll-like receptors
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Transfection
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Immune response
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Cerebrospinal fluid
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Gene expression
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Protein expression
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