miR-221/222 Compensates for Skp2-Mediated p27 Degradation and Is a Primary Target of Cell Cycle Regulation by Prostacyclin and cAMP

Paola Castagnino; Devashish Kothapalli; Elizabeth A. Hawthorne; Shu-Lin Liu; Tina Xu; Shilpa Rao; Yuval Yung; Richard K. Assoian

doi:10.1371/journal.pone.0056140

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Peer-reviewed

Research Article

miR-221/222 Compensates for Skp2-Mediated p27 Degradation and Is a Primary Target of Cell Cycle Regulation by Prostacyclin and cAMP

Paola Castagnino ,

Contributed equally to this work with: Paola Castagnino, Devashish Kothapalli

Affiliation Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Devashish Kothapalli ,

Contributed equally to this work with: Paola Castagnino, Devashish Kothapalli

Affiliation Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Elizabeth A. Hawthorne,

Affiliation Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Shu-Lin Liu,

Affiliation Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Tina Xu,

Affiliation Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Shilpa Rao,

Affiliation Molecular Profiling Facility, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Yuval Yung,

¤ Current address: Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel

Affiliation Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Richard K. Assoian

* E-mail: assoian@mail.med.upenn.edu

Affiliation Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

miR-221/222 Compensates for Skp2-Mediated p27 Degradation and Is a Primary Target of Cell Cycle Regulation by Prostacyclin and cAMP

Paola Castagnino,
Devashish Kothapalli,
Elizabeth A. Hawthorne,
Shu-Lin Liu,
Tina Xu,
Shilpa Rao,
Yuval Yung,
Richard K. Assoian

Published: February 7, 2013
https://doi.org/10.1371/journal.pone.0056140

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