Dysfunctional Activation of Neurotensin/IL-8 Pathway in Hepatocellular Carcinoma Is Associated with Increased Inflammatory Response in Microenvironment, More Epithelial Mesenchymal Transition in Cancer and Worse Prognosis in Patients

Jinpu Yu; Xiubao Ren; Yongzi Chen; Pengpeng Liu; Xiyin Wei; Hui Li; Guoguang Ying; Kexin Chen; Hans Winkler; Xishan Hao

doi:10.1371/journal.pone.0056069

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Open Access

Peer-reviewed

Research Article

Dysfunctional Activation of Neurotensin/IL-8 Pathway in Hepatocellular Carcinoma Is Associated with Increased Inflammatory Response in Microenvironment, More Epithelial Mesenchymal Transition in Cancer and Worse Prognosis in Patients

Jinpu Yu,

Affiliations TMUCIH-JnJ joint laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China, Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
⨯
Xiubao Ren,

Affiliation Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
⨯
Yongzi Chen,

Affiliation Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
⨯
Pengpeng Liu,

Affiliations TMUCIH-JnJ joint laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China, Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
⨯
Xiyin Wei,

Affiliation Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
⨯
Hui Li,

Affiliation Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
⨯
Guoguang Ying,

Affiliation Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
⨯
Kexin Chen,

Affiliation Department of Epidemiology, Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
⨯
Hans Winkler,

Affiliation TMUCIH-JnJ joint laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
⨯
Xishan Hao

* E-mail: hxs_yjp@yahoo.com

Affiliation TMUCIH-JnJ joint laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
⨯

Dysfunctional Activation of Neurotensin/IL-8 Pathway in Hepatocellular Carcinoma Is Associated with Increased Inflammatory Response in Microenvironment, More Epithelial Mesenchymal Transition in Cancer and Worse Prognosis in Patients

Jinpu Yu,
Xiubao Ren,
Yongzi Chen,
Pengpeng Liu,
Xiyin Wei,
Hui Li,
Guoguang Ying,
Kexin Chen,
Hans Winkler,
Xishan Hao

Published: February 13, 2013
https://doi.org/10.1371/journal.pone.0056069

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Hepatocellular carcinoma
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Gene expression
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Inflammation
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Cancers and neoplasms
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Microarrays
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