Characterization of Phosphofructokinase Activity in Mycobacterium tuberculosis Reveals That a Functional Glycolytic Carbon Flow Is Necessary to Limit the Accumulation of Toxic Metabolic Intermediates under Hypoxia

• Wai Yee Phong,

  Affiliations Novartis Institute for Tropical Diseases, Singapore, Singapore, Department of Microbiology, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Singapore

  ⨯
• Wenwei Lin,

  Affiliations Department of Microbiology, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Singapore, Singapore-Massachusetts Institute of Technology Alliance for Research and Technology (SMART), CREATE NUS Campus, Singapore, Singapore

  ⨯
• Srinivasa P. S. Rao,

  Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore

  ⨯
• Thomas Dick,

  Current address: Department of Microbiology, National University of Singapore, Singapore, Singapore

  Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore

  ⨯
• Sylvie Alonso ,

  * E-mail: micas@nus.edu.sg

  Affiliations Department of Microbiology, Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore, Singapore, Singapore-Massachusetts Institute of Technology Alliance for Research and Technology (SMART), CREATE NUS Campus, Singapore, Singapore

  ⨯
• Kevin Pethe

  Current address: Institute Pasteur-Korea, Gyeonggi Province, South Korea

  Affiliation Novartis Institute for Tropical Diseases, Singapore, Singapore

  ⨯