Novel Pancreatic Endocrine Maturation Pathways Identified by Genomic Profiling and Causal Reasoning

Alex Gutteridge; J. Michael Rukstalis; Daniel Ziemek; Mark Tié; Lin Ji; Rebeca Ramos-Zayas; Nancy A. Nardone; Lisa D. Norquay; Martin B. Brenner; Kim Tang; John D. McNeish; Rebecca K. Rowntree

doi:10.1371/journal.pone.0056024

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Open Access

Peer-reviewed

Research Article

Novel Pancreatic Endocrine Maturation Pathways Identified by Genomic Profiling and Causal Reasoning

Alex Gutteridge ,

* E-mail: alex.gutteridge@pfizer.com (AG); rownrk@yahoo.co.uk (RKR)

Affiliation Pfizer Regenerative Medicine, Cambridge, United Kingdom
⨯
J. Michael Rukstalis,

Affiliations Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America, Pfizer Cardiovascular and Metabolic Diseases, Cambridge, Massachusetts, United States of America
⨯
Daniel Ziemek,

Affiliation Pfizer Computational Sciences Center of Emphasis, Cambridge, Massachusetts, United States of America
⨯
Mark Tié,

Affiliation Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America
⨯
Lin Ji,

Affiliations Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America, Pfizer Cardiovascular and Metabolic Diseases, Cambridge, Massachusetts, United States of America
⨯
Rebeca Ramos-Zayas,

Affiliation Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America
⨯
Nancy A. Nardone,

Affiliation Pfizer Cardiovascular and Metabolic Diseases, Cambridge, Massachusetts, United States of America
⨯
Lisa D. Norquay,

Affiliation Pfizer Cardiovascular and Metabolic Diseases, Cambridge, Massachusetts, United States of America
⨯
Martin B. Brenner,

Affiliation Pfizer Cardiovascular and Metabolic Diseases, Cambridge, Massachusetts, United States of America
⨯
Kim Tang,

Affiliation Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America
⨯
John D. McNeish,

Affiliation Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America
⨯
Rebecca K. Rowntree

* E-mail: alex.gutteridge@pfizer.com (AG); rownrk@yahoo.co.uk (RKR)

Affiliation Pfizer Regenerative Medicine, Cambridge, Massachusetts, United States of America
⨯

Novel Pancreatic Endocrine Maturation Pathways Identified by Genomic Profiling and Causal Reasoning

Alex Gutteridge,
J. Michael Rukstalis,
Daniel Ziemek,
Mark Tié,
Lin Ji,
Rebeca Ramos-Zayas,
Nancy A. Nardone,
Lisa D. Norquay,
Martin B. Brenner,
Kim Tang

Published: February 13, 2013
https://doi.org/10.1371/journal.pone.0056024

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Gene expression
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Endocrine cells
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Cell differentiation
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