Evaluation of a Recombinant Double Mutant of Staphylococcal Enterotoxin B (SEB-H32Q/K173E) with Enhanced Antitumor Activity Effects and Decreased Pyrexia

Liwei Gu; Junjie Yue; Yuling Zheng; Xin Zheng; Jun Wang; Yanzi Wang; Jianchun Li; Yongqiang Jiang; Hua Jiang

doi:10.1371/journal.pone.0055892

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Open Access

Peer-reviewed

Research Article

Evaluation of a Recombinant Double Mutant of Staphylococcal Enterotoxin B (SEB-H32Q/K173E) with Enhanced Antitumor Activity Effects and Decreased Pyrexia

Liwei Gu ,

Contributed equally to this work with: Liwei Gu, Junjie Yue

Affiliations State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China, Department of Traditional Chinese Medicine Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
⨯
Junjie Yue ,

Contributed equally to this work with: Liwei Gu, Junjie Yue

Affiliation Beijing Institute of Biotechnology, Beijing, China
⨯
Yuling Zheng,

Affiliation State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China
⨯
Xin Zheng,

Affiliations State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China, Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
⨯
Jun Wang,

Affiliations State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China, Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
⨯
Yanzi Wang,

Affiliation Department of Pharmacy, Jiangsu Provincial Xuzhou Pharmaceutical Vocational College, Xuzhou, China
⨯
Jianchun Li ,

* E-mail: lijianchun0317@gmail.com (JCL); jiangyq@nic.bmi.ac.cn (YQJ); weishengwuliuxingbing@hotmail.com (HJ)

Affiliation Department of Traditional Chinese Medicine Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
⨯
Yongqiang Jiang ,

* E-mail: lijianchun0317@gmail.com (JCL); jiangyq@nic.bmi.ac.cn (YQJ); weishengwuliuxingbing@hotmail.com (HJ)

Affiliation State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China
⨯
Hua Jiang

* E-mail: lijianchun0317@gmail.com (JCL); jiangyq@nic.bmi.ac.cn (YQJ); weishengwuliuxingbing@hotmail.com (HJ)

Affiliation State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China
⨯

Evaluation of a Recombinant Double Mutant of Staphylococcal Enterotoxin B (SEB-H32Q/K173E) with Enhanced Antitumor Activity Effects and Decreased Pyrexia

Liwei Gu,
Junjie Yue,
Yuling Zheng,
Xin Zheng,
Jun Wang,
Yanzi Wang,
Jianchun Li,
Yongqiang Jiang,
Hua Jiang

Published: February 6, 2013
https://doi.org/10.1371/journal.pone.0055892

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