Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation

Jun Tang; Trisha Agrawal; Qian Cheng; Like Qu; Michael D. Brewer; Jiandong Chen; Xiaolu Yang

doi:10.1371/journal.pone.0055813

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Open Access

Peer-reviewed

Research Article

Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation

Jun Tang ,

Contributed equally to this work with: Jun Tang, Trisha Agrawal

Current address: State Key Laboratory of Agrobiotechnology, College of Veterinary Medicine, China Agricultural University, Beijing, China

Affiliation Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Trisha Agrawal ,

Contributed equally to this work with: Jun Tang, Trisha Agrawal

Affiliation Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Qian Cheng,

Affiliation Department of Molecular Oncology, Moffitt Cancer Center, Tampa, Florida, United States of America
⨯
Like Qu,

Current address: Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China

Affiliation Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Michael D. Brewer,

Affiliation Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Jiandong Chen,

Affiliation Department of Molecular Oncology, Moffitt Cancer Center, Tampa, Florida, United States of America
⨯
Xiaolu Yang

* E-mail: xyang@mail.med.upenn.edu

Affiliation Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation

Jun Tang,
Trisha Agrawal,
Qian Cheng,
Like Qu,
Michael D. Brewer,
Jiandong Chen,
Xiaolu Yang

Published: February 6, 2013
https://doi.org/10.1371/journal.pone.0055813

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Phosphorylation
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DNA damage
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Immunoprecipitation
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Transfection
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Small interfering RNA
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Plasmid construction
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Actins
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Gene expression
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