Sensitive Detection of Pre-Existing BCR-ABL Kinase Domain Mutations in CD34+ Cells of Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia Patients Is Associated with Imatinib Resistance: Implications in the Post-Imatinib Era

• Zafar Iqbal ,

  Contributed equally to this work with: Zafar Iqbal, Aamer Aleem

  * E-mail: iqbalz@ksau-hs.edu.sa

  Affiliations College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), National Guards Health Affairs, Riyadh, Kingdom of Saudi Arabia, School of Biological Sciences, University of Sargodha, Sargodha, Pakistan, Institute of Molecular Biology and Biotechnology and Centre for Research in Molecular Medicine, the University of Lahore, Lahore, Pakistan, Higher Education Commission Program in “Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES)”, HOPES Group, Health Sciences Research Laboratories, Department of Zoology, University of the Punjab, Lahore, Pakistan

  ⨯
• Aamer Aleem ,

  Contributed equally to this work with: Zafar Iqbal, Aamer Aleem

  Affiliation Department of Medicine, Division of Hematology/Oncology, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia

  ⨯
• Mudassar Iqbal,

  Affiliations Foreign Faculty, Asian Medical Institute, Kant City, National Surgical Centre, Bishkek, Kyrgyzstan, Higher Education Commission Program in “Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES)”, HOPES Group, Health Sciences Research Laboratories, Department of Zoology, University of the Punjab, Lahore, Pakistan

  ⨯
• Mubashar Iqbal Naqvi,

  Affiliations Computer Sciences and Bio-informatics Laboratory, Government. Elementary School Chak 19 S.B., Sargodha, Pakistan, Higher Education Commission Program in “Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES)”, HOPES Group, Health Sciences Research Laboratories, Department of Zoology, University of the Punjab, Lahore, Pakistan

  ⨯
• Ammara Gill,

  Affiliations Springfield, Missouri, United States of America, Higher Education Commission Program in “Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES)”, HOPES Group, Health Sciences Research Laboratories, Department of Zoology, University of the Punjab, Lahore, Pakistan

  ⨯
• Abid Sohail Taj,

  Affiliation Institute of Radiotherapy and Nuclear Medicine, Peshawar, Pakistan

  ⨯
• Abdul Qayyum,

  Affiliation Department of Oncology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan

  ⨯
• Najeeb ur-Rehman,

  Affiliation Medilaser, Lahore, Pakistan

  ⨯
• Ahmad Mukhtar Khalid,

  Affiliation School of Biological Sciences, University of Sargodha, Sargodha, Pakistan

  ⨯
• Ijaz Hussain Shah,

  Affiliation Department of Oncology, Allied Hospital and Punjab Medical College, Faisalabad, Pakistan

  ⨯
• Muhammad Khalid,

  Affiliation Department of Oncology, Allied Hospital and Punjab Medical College, Faisalabad, Pakistan

  ⨯
• Riazul Haq,

  Affiliations Health Centre, University of Texas San Antonio, San Antonio, Texas, United States of America, Institute of Molecular Biology and Biotechnology and Centre for Research in Molecular Medicine, the University of Lahore, Lahore, Pakistan

  ⨯
• Mahwish Khan,

  Affiliations Institute of Molecular Biology and Biotechnology and Centre for Research in Molecular Medicine, the University of Lahore, Lahore, Pakistan, Higher Education Commission Program in “Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES)”, HOPES Group, Health Sciences Research Laboratories, Department of Zoology, University of the Punjab, Lahore, Pakistan

  ⨯
• Shahid Mahmood Baig,

  Affiliation Human Molecular Genetics Group, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan

  ⨯
• Abid Jamil,

  Affiliation Post-graduate Medical Institute, Hayatabad Medical Complex, Peshawar, Pakistan

  ⨯
• Muhammad Naeem Abbas,

  Affiliation Higher Education Commission Program in “Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES)”, HOPES Group, Health Sciences Research Laboratories, Department of Zoology, University of the Punjab, Lahore, Pakistan

  ⨯
• Muhammad Absar,

  Affiliation Higher Education Commission Program in “Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES)”, HOPES Group, Health Sciences Research Laboratories, Department of Zoology, University of the Punjab, Lahore, Pakistan

  ⨯
• Amer Mahmood,

  Affiliation Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia

  ⨯
• Mahmood Rasool,

  Affiliation Centre of Excellence in Genomic Medicine Research, King Abdulaziz University Jeddah, Kingdom of Saudi Arabia

  ⨯
•  [ ... ],
• Tanveer Akhtar

  Affiliation Higher Education Commission Program in “Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES)”, HOPES Group, Health Sciences Research Laboratories, Department of Zoology, University of the Punjab, Lahore, Pakistan

  ⨯
• [ view all ]
• [ view less ]