Tissue Inhibitor of Metalloproteinases-3 Peptides Inhibit Angiogenesis and Choroidal Neovascularization in Mice

Jian Hua Qi; Quteba Ebrahem; Mariya Ali; Alecia Cutler; Brent Bell; Nicholas Prayson; Jonathan Sears; Vera Knauper; Gillian Murphy; Bela Anand-Apte

doi:10.1371/journal.pone.0055667

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Peer-reviewed

Research Article

Tissue Inhibitor of Metalloproteinases-3 Peptides Inhibit Angiogenesis and Choroidal Neovascularization in Mice

Jian Hua Qi,

Affiliation Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, United States of America
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Quteba Ebrahem,

Affiliation Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Mariya Ali,

Affiliation Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, United States of America
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Alecia Cutler,

Affiliation Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, United States of America
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Brent Bell,
Nicholas Prayson,

Affiliation Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, United States of America
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Jonathan Sears,

Affiliation Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, United States of America
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Vera Knauper,

Affiliation Metalloproteinase Research Group, Matrix Biology and Tissue Repair Research Unit, Dental School, Cardiff University, Heath Park, Cardiff, Wales, United Kingdom
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Gillian Murphy,

Affiliation Cancer Research United Kingdom Cambridge Research Institute, The Li Ka Shing Centre, Robinson Way, Cambridge, United Kingdom
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Bela Anand-Apte

* E-mail: anandab@ccf.org

Affiliations Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, United States of America, Dept. of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, United States of America
⨯

Tissue Inhibitor of Metalloproteinases-3 Peptides Inhibit Angiogenesis and Choroidal Neovascularization in Mice

Jian Hua Qi,
Quteba Ebrahem,
Mariya Ali,
Alecia Cutler,
Brent Bell,
Nicholas Prayson,
Jonathan Sears,
Vera Knauper,
Gillian Murphy,
Bela Anand-Apte

Published: March 1, 2013
https://doi.org/10.1371/journal.pone.0055667

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Endothelial cells
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Angiogenesis
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Immunoprecipitation
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