βKlotho Suppresses Tumor Growth in Hepatocellular Carcinoma by Regulating Akt/GSK-3β/Cyclin D1 Signaling Pathway

Xiaoming Ye; Yu Guo; Qi Zhang; Wenjie Chen; Xuefeng Hua; Wei Liu; Yang Yang; Guihua Chen

doi:10.1371/journal.pone.0055615

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Open Access

Peer-reviewed

Research Article

βKlotho Suppresses Tumor Growth in Hepatocellular Carcinoma by Regulating Akt/GSK-3β/Cyclin D1 Signaling Pathway

Xiaoming Ye ,

Contributed equally to this work with: Xiaoming Ye, Yu Guo, Qi Zhang

Affiliations Department of General Surgery, Lingnan Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, Guangdong, China, Hepatology Laboratory, Hospital for Liver Disease, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Yu Guo ,

Contributed equally to this work with: Xiaoming Ye, Yu Guo, Qi Zhang

Affiliations Department of General Surgery, Lingnan Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, Guangdong, China, Hepatology Laboratory, Hospital for Liver Disease, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Qi Zhang ,

Contributed equally to this work with: Xiaoming Ye, Yu Guo, Qi Zhang

Affiliations Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, Guangdong, China, Hepatology Laboratory, Hospital for Liver Disease, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Wenjie Chen,

Affiliations Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, Guangdong, China, Hepatology Laboratory, Hospital for Liver Disease, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Xuefeng Hua,

Affiliation Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, Guangdong, China
⨯
Wei Liu,

Affiliation Hepatology Laboratory, Hospital for Liver Disease, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Yang Yang ,

* E-mail: chgh1955@263.net (GC) (YY); yysysu@163.com (YY) (GC)

Affiliations Department of General Surgery, Lingnan Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, Guangdong, China, Hepatology Laboratory, Hospital for Liver Disease, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Guihua Chen

* E-mail: chgh1955@263.net (GC) (YY); yysysu@163.com (YY) (GC)

Affiliations Department of General Surgery, Lingnan Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, Guangdong, China, Hepatology Laboratory, Hospital for Liver Disease, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯

βKlotho Suppresses Tumor Growth in Hepatocellular Carcinoma by Regulating Akt/GSK-3β/Cyclin D1 Signaling Pathway

Xiaoming Ye,
Yu Guo,
Qi Zhang,
Wenjie Chen,
Xuefeng Hua,
Wei Liu,
Yang Yang,
Guihua Chen

Published: January 30, 2013
https://doi.org/10.1371/journal.pone.0055615

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