Molecular Mechanisms Underlying the Analgesic Property of Intrathecal Dexmedetomidine and Its Neurotoxicity Evaluation: An In Vivo and In Vitro Experimental Study

Hongxing Zhang; Fang Zhou; Chen Li; Min Kong; He Liu; Peng Zhang; Song Zhang; Junli Cao; Licai Zhang; Hong Ma

doi:10.1371/journal.pone.0055556

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Peer-reviewed

Research Article

Molecular Mechanisms Underlying the Analgesic Property of Intrathecal Dexmedetomidine and Its Neurotoxicity Evaluation: An In Vivo and In Vitro Experimental Study

Hongxing Zhang ,

Contributed equally to this work with: Hongxing Zhang, Fang Zhou, Chen Li

Affiliations The First Clinical College, China Medical University, Shenyang, Liaoning, People’s Republic of China, Department of Anesthesiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China
⨯
Fang Zhou ,

Contributed equally to this work with: Hongxing Zhang, Fang Zhou, Chen Li

Affiliations The First Clinical College, China Medical University, Shenyang, Liaoning, People’s Republic of China, Jiangsu Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, Jiangsu, People’s Republic of China, School of Nursing, Xuzhou Medical College, Xuzhou, Jiangsu, People’s Republic of China
⨯
Chen Li ,

Contributed equally to this work with: Hongxing Zhang, Fang Zhou, Chen Li

Affiliation Jiangsu Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, Jiangsu, People’s Republic of China
⨯
Min Kong,

Affiliation Jiangsu Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, Jiangsu, People’s Republic of China
⨯
He Liu,

Affiliations The First Clinical College, China Medical University, Shenyang, Liaoning, People’s Republic of China, Jiangsu Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, Jiangsu, People’s Republic of China
⨯
Peng Zhang,

Affiliation Jiangsu Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, Jiangsu, People’s Republic of China
⨯
Song Zhang,

Affiliation Jiangsu Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, Jiangsu, People’s Republic of China
⨯
Junli Cao,

Affiliations Jiangsu Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, Jiangsu, People’s Republic of China, Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, People’s Republic of China
⨯
Licai Zhang,

Affiliation Jiangsu Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, Jiangsu, People’s Republic of China
⨯
Hong Ma

* E-mail: mahong5466@hotmail.com

Affiliation Department of Anesthesiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China
⨯

Molecular Mechanisms Underlying the Analgesic Property of Intrathecal Dexmedetomidine and Its Neurotoxicity Evaluation: An In Vivo and In Vitro Experimental Study

Hongxing Zhang,
Fang Zhou,
Chen Li,
Min Kong,
He Liu,
Peng Zhang,
Song Zhang,
Junli Cao,
Licai Zhang,
Hong Ma

Published: February 7, 2013
https://doi.org/10.1371/journal.pone.0055556

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