Losartan Prevents Heart Fibrosis Induced by Long-Term Intensive Exercise in an Animal Model

Gemma Gay-Jordi; Eduard Guash; Begoña Benito; Josep Brugada; Stanley Nattel; Lluís Mont; Anna Serrano-Mollar

doi:10.1371/journal.pone.0055427

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Open Access

Peer-reviewed

Research Article

Losartan Prevents Heart Fibrosis Induced by Long-Term Intensive Exercise in an Animal Model

Gemma Gay-Jordi,

Affiliations Department of Experimental Pathology, Institut d'Investigacions Biomèdiques de Barcelona (IIBB-CSIC), Barcelona, Catalonia, Spain, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain
⨯
Eduard Guash,

Affiliations Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain, Cardiology Department, The Thorax Institute, Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain, Research Center, Montreal Heart Institute and Université de Montréal, Montréal, Quebec, Canada
⨯
Begoña Benito,

Affiliations Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain, Cardiology Department, The Thorax Institute, Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain, Research Center, Montreal Heart Institute and Université de Montréal, Montréal, Quebec, Canada
⨯
Josep Brugada,

Affiliations Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain, Cardiology Department, The Thorax Institute, Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain
⨯
Stanley Nattel,

Affiliation Research Center, Montreal Heart Institute and Université de Montréal, Montréal, Quebec, Canada
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Lluís Mont,

Affiliations Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain, Cardiology Department, The Thorax Institute, Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain
⨯
Anna Serrano-Mollar

* E-mail: anna.serranomollar@iibb.csic.es

Affiliations Department of Experimental Pathology, Institut d'Investigacions Biomèdiques de Barcelona (IIBB-CSIC), Barcelona, Catalonia, Spain, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain
⨯

Losartan Prevents Heart Fibrosis Induced by Long-Term Intensive Exercise in an Animal Model

Gemma Gay-Jordi,
Eduard Guash,
Begoña Benito,
Josep Brugada,
Stanley Nattel,
Lluís Mont,
Anna Serrano-Mollar

Published: February 1, 2013
https://doi.org/10.1371/journal.pone.0055427

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Exercise
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Sedentary behavior
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Fibrosis
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Heart
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Collagens
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Receptor antagonist therapy
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