Allosteric Regulation of Serine Protease HtrA2 through Novel Non-Canonical Substrate Binding Pocket

Open Access

Peer-reviewed

Research Article

Pruthvi Raj Bejugam ,

Contributed equally to this work with: Pruthvi Raj Bejugam, Raja R. Kuppili

Affiliation Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India
⨯
Raja R. Kuppili ,

Contributed equally to this work with: Pruthvi Raj Bejugam, Raja R. Kuppili

Affiliation Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India
⨯
Nitu Singh,

Affiliation Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India
⨯
Nikhil Gadewal,

Affiliation Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India
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Lalith K. Chaganti,

Affiliation Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India
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G. Madhavi Sastry,

Affiliation Schrödinger, Sanali Infopark, Banjara Hills, Hyderabad, India
⨯
Kakoli Bose

* E-mail: kbose@actrec.gov.in

Affiliation Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India
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Proteases
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Allosteric regulation
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Serine proteases
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Protein structure comparison
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Protein structure
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Biochemical simulations
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Molecular dynamics
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Protein domains
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