Intravenous Delivery of HIV-Based Lentiviral Vectors Preferentially Transduces F4/80+ and Ly-6C+ Cells in Spleen, Important Target Cells in Autoimmune Arthritis

Open Access

Peer-reviewed

Research Article

Ben T. van den Brand,

Affiliation Rheumatology Research and Advanced Therapeutics, Department of Rheumatology Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Eline A. Vermeij,

Affiliation Rheumatology Research and Advanced Therapeutics, Department of Rheumatology Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Claire E. J. Waterborg,

Affiliation Rheumatology Research and Advanced Therapeutics, Department of Rheumatology Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Onno J. Arntz,

Affiliation Rheumatology Research and Advanced Therapeutics, Department of Rheumatology Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Michael Kracht,

Affiliation Rudolf-Buchheim-Institute of Pharmacology, Justus-Liebig-University Giessen, Giessen, Germany
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Miranda B. Bennink,

Affiliation Rheumatology Research and Advanced Therapeutics, Department of Rheumatology Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Wim B. van den Berg,

Affiliation Rheumatology Research and Advanced Therapeutics, Department of Rheumatology Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Fons A. J. van de Loo

* E-mail: a.vandeloo@reuma.umcn.nl

Affiliation Rheumatology Research and Advanced Therapeutics, Department of Rheumatology Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Lentivirus
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Spleen
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Arthritis
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Antigen-presenting cells
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Macrophages
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Inflammation
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Intravenous injections
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Monocytes
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