Nebulized Fibrinolytic Agents Improve Pulmonary Fibrinolysis but Not Inflammation in Rat Models of Direct and Indirect Acute Lung Injury

• Jorrit J. Hofstra ,

  * E-mail: j.j.hofstra@amc.uva.nl

  Affiliations Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands, Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands, Department of Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands, Department of Medical Microbiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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• Alexander D. Cornet,

  Affiliation Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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• Paul J. Declerck,

  Affiliation Laboratory for Pharmaceutical Biology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Leuven, Leuven, Belgium

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• Barry Dixon,

  Affiliation Department of Intensive Care Medicine, St. Vincent’s Hospital, Melbourne, Australia

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• Hamid Aslami,

  Affiliations Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands, Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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• Alexander P. J. Vlaar,

  Affiliations Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands, Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands, Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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• Joris J. Roelofs,

  Affiliation Department of Pathology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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• Tom van der Poll,

  Affiliation Centre for Experimental and Molecular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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• Marcel Levi,

  Affiliation Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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• Marcus J. Schultz

  Affiliations Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands, Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands, HERMES Critical Care Group, Amsterdam, The Netherlands

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